伏立康和唑伊曲康唑治疗慢性阻塞性肺疾病合并侵袭性肺曲霉病的对照研究  

The therapeutic effect of voriconazole compare effectively with those of itraconazole to chronic obstructive pulmonary disease patients complicated with invasive pulmonary aspergillosis

作　　者：梁丽萍[1] 周燕斌[2] 左万里[1] 黄炎明[1] 

机构地区：[1]中山大学附属江门医院江门市中心医院呼吸内科,广东江门529030 [2]中山大学附属第一医院呼吸内科

出　　处：《临床内科杂志》2013年第5期334-336,共3页Journal of Clinical Internal Medicine

摘　　要：目的 探讨应用伏立康唑对照伊曲康唑治疗慢性阻塞性肺疾病合并侵袭性肺曲霉病患者的临床疗效.方法 收集中山大学附属第一医院及中山大学附属江门医院2005年1月～2012年8月收治的确诊为慢性阻塞性肺疾病合并侵袭性肺曲霉病,且初始时选用伏立康唑或伊曲康唑治疗的患者43例,分为伏立康唑组（24例）和伊曲康唑组（19例）,对两组患者的临床资料进行回顾性分析.结果 两组患者,使用广谱抗生素、肺功能、营养状态等影响因素及临床症状、体征等比较差异均无统计学意义.伏立康唑组患者治愈或好转率（79.17％）明显高于伊曲康唑组（52.63％,P＜0.05）.伏立康唑补救治疗有效率为60.00％ （3/5）.结论 初始选用伏立康唑治疗慢性阻塞性肺疾病并发侵袭性肺曲霉病的疗效明显优于伊曲康唑.Objective To compare the efficacy between voriconazole and itraconazole to chronic obstructive pulmonary disease patients complicated with invasive pulmonary aspergillosis. Methods Forty-three patients diagnosed with chronic obstructive pulmonary disease patients complicated with invasive pulmonary aspergillosis from January 2005 to August 2012 were studied retrospectively and evaluated the therapeutic efficacy between voriconazole and itraconazole. Results Among the 43 cases, 19 out of 24 patients were cured or got better treated with oriconazole, and 10 out of 19 with those of itraconazole. Conclusion Voriconazole therapy may produce superior response than itraconazole treatment group in chronic obstructive pulmonary disease patients complicated with invasive pulmonary aspergillosis.

关 键 词：慢性阻塞性肺疾病 侵袭性肺曲霉病 伏立康唑 伊曲康唑 

分 类 号：R563[医药卫生—呼吸系统]