枸杞多糖对糖尿病小鼠模型免疫功能的影响  

The Effects of LBP-D on Immune Functions in Alloxan-Induced Diabetes Mice

作　　者：王玲[1] 李维波[2] 邓学端[1] 张才军[1] 谢蒲伶[1] 蒋绿芝[3] 赵翀 

机构地区：[1]昆明医学院微生物学与免疫学教研室,昆明650031 [2]昆明医学院物理学教研室 [3]昆明医学院第二附属医院内分泌科 [4]北京中国医学科学院动物所生殖生物学实验室

出　　处：《上海免疫学杂志》2000年第3期159-162,共4页Shanghai Journal of Immunology

基　　金：云南省教委应用基金资助项目!(9612117)

摘　　要：利用静脉注射四氧嘧啶 ( 10 0mg/kg)诱导制备糖尿病小鼠模型 ,观察LBP D对四氧嘧啶致糖尿病小鼠免疫功能的影响。研究表明 ,小鼠在注射四氧嘧啶后 72h ,灌胃 (ig )给予LBP D ,连续 10d ,糖尿病小鼠NS对照组免疫功能明显降低 ,而LBP D组显示LBP D具有明显促进小鼠淋巴细胞增殖、调节T淋巴细胞亚群及提高IL 1和IL 2水平的功能 ,使四氧嘧啶糖尿病小鼠免疫功能恢复接近正常。研究结果显示 ,LBPAn experiment diabetes mouse model was induced by intravenous injections of alloxan monohydrate (100mg/kg),and LBPD was administrated 72 hours after injections of alloxan for 10 successive days It was found that LBPD had a remarkablly enhancing effects on the immune functions including the enhancement of lymphocyte proliferation,upregulation in the numbers of T lymphocyte subsets,elevations of the IL1 and IL2 levels,and recovery of the immunocompromised functions of the alloxan-induced diabetes mice near to normal These experimental results implicate that LBPD appears to have a immunoregulatory effect on the alloxaninduced diabetes mice

关 键 词：枸杞多糖 糖尿病 免疫功能 T细胞亚群 

分 类 号：R392.6[医药卫生—免疫学] R979.5[医药卫生—基础医学]