2,6-二甲基苯甲酸的合成工艺研究  

Studies on the Synthesis of 2,6-dimethyl Benzoic Acid

作　　者：赵迎春[1] 张学楷[1] 黄龙江[1] 滕大为[1] 

机构地区：[1]青岛科技大学化工学院,青岛266042

出　　处：《科学技术与工程》2013年第16期4724-4726,共3页Science Technology and Engineering

基　　金：教育部归国留学人员科研基金项目(201000265)资助

摘　　要：以2,6-二甲基溴苯为原料,经氰基化,两步水解等反应合成了2,6-二甲基苯甲酸,并对氰基水解反应的工艺条件进行了优化。先将氰基在碱性条件下水解成酰胺,收率:100%;再在酸性条件下水解酰胺,得到最优的酰胺水解条件是:酰胺与65%硫酸的配比为1 g∶10 mL,水解温度110℃,水解时间12 h,收率达到:85%。2,6-dimethyl benzoic acid was synthesized by the reaction of nitrilization and then hydrolysis from the starting material 2,6-dimethyl bromobenzene; and the optimized reaction condition was obtained. 2,6- dimeth- ylbenzonitrile was firstly hydrolyzed to 2,6-dimethylbenzamide in the basic condition with 100% yield, the target acid was obtained by hydr -olysis of amide in acid condition, the optimization of hydrolysis of 2,6-di methylbenzo- amide is： amide： 65%H2S04 = I： I0 mL, the reaction temperat ure was i10 ~C and the reaction time was 12 h, the yield was 85%.

关 键 词：2 6-二甲基苯甲酸 合成 酰胺水解 

分 类 号：TQ245.12[化学工程—有机化工]