发光细菌法检测不同形状CdS纳米材料毒性  

On the Effect of Particle Shape on Toxicity of CdS Nanomaterials Using Luminous Bacteria

作　　者：隆异娟[1] 高梅[1] 梁立平[1] 郑鹄志[1] 

机构地区：[1]西南大学化学化工学院,重庆400715

出　　处：《西南大学学报（自然科学版）》2013年第5期116-121,共6页Journal of Southwest University(Natural Science Edition)

基　　金：国家自然科学基金资助项目(21175110);西南大学中央高校基本科研业务费(XDJK2012C048);西南大学博士基金资助项目(SWU112071);西南大学青年基金资助项目(SWNUQ2005007)

摘　　要：采用发光细菌法考察了纳米材料的形状对其毒性的影响.通过对硫化镉(CdS)量子点、米粒状的硫化镉棒以及多臂硫化镉棒毒性的评价,发现多臂硫化镉棒在三者中尺寸最大,毒性最大;而粒径最小的硫化镉量子点毒性最小.实验证实,这3种硫化镉纳米粒子均可进入细菌,产生不同的毒性.紫外照射和维生素C实验证明了这几种硫化镉纳米材料的毒性差异与其形状有关,其原因在于不同形状的纳米粒子对细胞膜具有不同的刺伤能力.The effect of particle shape on the toxicity of nanomaterials was investigated using luminous bac teria as a microbial sensor. CdS quantum dots （QDs）, rice-like CdS nanorods and multi-armed nanorods were modified with dihydrolipoic acid （DHLA） and their toxicity was assayed, separately. Of the three CdS nanomaterials studied, multi-armed rods had the biggest size and the maximal toxicity, and QDs had the smallest size and the lowest toxicity. TEM confirmed that three kinds of CdS nanomaterials can all penetrate into bacterial cells. UV illumination and vitamin C exposure experiments showed that the mech- anism of toxicity of quantum dots was different from that of nanorods. The shape dependent toxicity of CdS nanomaterials can be attributed to their different capacity for impaling cell membranes.

关 键 词：发光细菌 CdS纳米材料 毒性 粒子形状 

分 类 号：O656[理学—分析化学]