院内念珠菌感染的药敏分析及临床分析  

Analysis of clinical distribution and drug susceptivity of Candida infection

作　　者：田振楠[1] 刘晓民[1] 马雨霞[1] 陈晶莹[1] 

机构地区：[1]哈尔滨医科大学附属第一医院,黑龙江哈尔滨150001

出　　处：《临床肺科杂志》2013年第7期1201-1202,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的了解并对比白色念珠菌与非白色念珠菌的临床分布、药敏情况。方法分析411株念珠菌的来源、科室分布,对比白色念珠菌与非白色念珠菌的药敏结果、危险因素等。结果 411株念珠菌的标本以痰液最多;ICU分离率最高;呼吸系统疾病最多;年龄≥65岁及侵袭性操作、药物使用,分别为感染白色念珠菌与非白色念珠菌的独立危险因素;念珠菌对两性霉素B最敏感;白色念珠菌对氟康唑、氟胞嘧啶、伊曲康唑、伏立康唑敏感性高于非白色念珠菌,对氟康唑、伊曲康唑的耐药率低于非白色念珠菌。结论加强对念珠菌耐药性的监测有助于减少耐药菌株的产生。Objective To understand and compare the clinical distribution and drug susceptivity of Candida albicans and non-al- bicans Candida. Methods The sources and distribution of 411 strains of Candidas were analyzed. The results of drug susceptivity and risk factors of Candida albicans and Non-albicans Candida were compared. Results Most specimens of the 411 strains of Candidas were from sputum. ICU had the highest separate rate. Most patients infected with Candidas were complicated with respiratory diseases. The in- dependent risk factors included patients older than 65 years, invasive operations and drug usage. Candida was most sensitive to amphoteri- tin B. Candida albieans showed a higher sensitivity to flueonazole, flucytosine, itraconazole, voriconazole azole and lower resistance rates to fluconazole and itraconazole than non-Candida albicans did. Conclusion The effective way to reduce the generation of drug-resistant strains is to strengthen the monitoring to Candida resistance.

关 键 词：白色念珠菌 非白色念珠菌 临床分析 耐药性 

分 类 号：R446.5[医药卫生—诊断学]