缺血修饰白蛋白在小儿病毒性心肌炎中的应用  

Application of ischemia modified albumin in children with viral myocarditis

作　　者：魏丽[1] 黄星原[1] 王世红[1] 邓巍[1] 李小鸥[1] 何兵[1] 

机构地区：[1]武汉大学人民医院儿I科,武汉430060

出　　处：《岭南心血管病杂志》2013年第3期274-275,共2页South China Journal of Cardiovascular Diseases

摘　　要：目的评价缺血修饰白蛋白(ischemia modified albumin,IMA)对小儿病毒性心肌炎的诊疗价值。方法选取42例病毒性心肌炎患儿于入院后30 min内及治疗一周后测IMA及肌钙蛋白I(troponin I,TnI)、心肌型肌酸激酶同工酶(MB isoenzyme of creatine kinase,CK-MB)浓度,并与40例同期正常对照组比较分析。结果病毒性心肌炎治疗前IMA浓度低于对照组,TnI、CK-MB高于对照组,差异有统计学意义[(57.20±12.30)U.mL-1vs.(77.50±12.10)U﹒mL-1,P<0.05;(2.10±0.12)ng.mL-1vs.(0.03±0.01)ng.mL-1,P<0.05;(62.33±8.58)U.L-1vs.(9.60±6.85)U.L-1,P<0.05];治疗一周后与对照组相比,差异无统计学意义(P>0.05)。IMA对小儿病毒性心肌炎诊断的灵敏度为97.62%,特异度85%。结论检测IMA对病毒性心肌炎的早期诊断及疗效判断,有一定临床价值。Objectives To evaluate the clinical value of ischemia modified albumin （IMA） in children with viral myoearditis. Methods Serum IMA, troponin I （TnI） and MB isoenzyme of creatine kinase （CK-MB） were detected in 42 children with viral myocarditis within 30 minutes in admission and after treating for a week. Compared the levels with those in control group （40 healthy children）. Results Compared with control group, level of IMA in children with viral myoearditis before treating was significant lower, and levels of TnI and CK-MB were significant higher [（57.20±12.30） U·mL-1 vs. （77.50±12.10） U·mL-1, P〈0.05; （2.10±0.12） ng.mL-1 vs. （0.03±0.01） ng·mL-1, P〈0.05; （62.33±8.58） U·L-1 vs. （9.60±6.85） U·L-1, P〈0.051. All indicators after treating were not significantly different compared with those of control group （P〉0.05）. Sensitivity and specificity of IMA were 97.62% and 85% respectively for diagnosis of viral myoearditis in children. Conclusions IMA can be used in early diagnosis of viral myocarditis and evaluated for the clinical effect.

关 键 词：病毒性心肌炎 缺血修饰白蛋白 小儿 

分 类 号：R542.21[医药卫生—心血管疾病]