金雀异黄酮-4'-O糖苷的合成方法研究  

Advances in Glycosidation Modification of Genistein 4′-O-glycoside Oside

作　　者：郭瑞霞[1] 冯俊霞[1] 贾会珍[1] 王娟[1] 岳红坤[1] 何敬宇[1] 

机构地区：[1]石家庄学院化工学院,河北石家庄050035

出　　处：《河南化工》2013年第7期36-38,共3页Henan Chemical Industry

基　　金：河北省科学技术研究与发展计划项目(11276427)

摘　　要：以金雀异黄酮为原料,采用固-液相转移催化法,以冠醚为相转移催化剂,在叔丁醇钾的存在下与四乙酰溴代葡萄糖反应,以较高的区域选择性合成了金雀异黄酮4'-O-β-D-半乳糖苷和金雀异黄酮4'-O-β-D-葡萄糖苷;并考察了投料次序、碱、相转移催化剂、反应时间等对糖苷化反应收率的影响。Using Genistein as material, crown ether as phase transfer catalyst, under potassium tert - bu- toxide existing, genistein and 4 ethyl acetyl hromination glucose reaction, the genistein 4＇ - O - β - D - galactoside and genistein 4＇ - O - β - D - glucoside is sythsised with higher regioselectivity, the influences of reaction conditions such as mix - order, alkali, phas transfer catalyst and reaction time are investigated.

关 键 词：金雀异黄酮 糖苷 固-液相转移催化 冠醚 

分 类 号：TQ460.3[化学工程—制药化工]