SLE患者性激素水平的临床研究及免疫抑制剂对其影响  

Clinical study of sex hormone levels in patients with SLE and immunosuppressants' influence

作　　者：刘潇潇[1] 练颖 雷丽华[1] 

机构地区：[1]成都市第一人民医院血液风湿科,四川成都610041

出　　处：《四川医学》2013年第4期479-481,共3页Sichuan Medical Journal

摘　　要：目的研究女性系统性红斑狼疮患者(SLE)体内性激素水平及使用免疫抑制剂后对其影响。方法随机选取56例18岁～40岁女性SLE患者及相同年龄段正常女性,抽取卵泡期血,使用电化学法检测血中性激素:雌二醇(E2)、睾酮(T)、催乳素(PRL),促卵泡素(FSH)水平,并对比研究其水平高低与病情活动度关系。56例SLE患者随机分为两组,分别使用CTX与雷公藤多甙治疗,半年后血清中性激素水平的比较。结果 SLE患者血清中PRL高于正常对照组(P<0.05),T明显低于正常对照组,与病情活动度负相关(P<0.01);T值、E2/T比值与病情活动度呈正相关;活动期SLE患者血清中E2高于静止期(P<0.05)。分别使用免疫抑制剂半年后,血清中E2下降,TSH升高(P<0.05),两组差异无统计学意义(P>0.05)结论性激素与SLE的发病及病情活动关系密切,使用免疫抑制剂后可使血清中E2下降,但可致卵巢早衰。Objective A study of female sex hormone levels and the use of immunosuppressive agents in patients with systemic lupus erythematosus （SLE）. Methods We randomly selected 56 and 18-year-old to 40-year-old female SLE patients and the same age normal female to extract follicular phase blood, the use of sex hormones （E2, T, PRL, FSH） level in the blood of electrochemical detection, and to study the level relations with disease activity. The 56 SLE patients were randomly divided into two groups, respectively CTX or tripterygium glycosides, serum levels were compared offer 6 months. Results SLE serum PRL,TSH in SLE were higher than that in the normal control group （ P 〈 0.05 ） and positively correlated with disease activity, T was significantly lower than that in the normal control group （P 〈 0. 05） and negatively correlated with disease activity. Conclusion Sex hormones are closely related to the disease activity of SLE.

关 键 词：系统性红斑狼疮 性激素 免疫抑制剂 病情活动度 

分 类 号：R593.241[医药卫生—内科学]