天然紫杉烷类二萜化合物的核磁共振碳谱规律的探讨  

The ^(13)C-NMR Features of Natural Taxane Diterpenoid Compounds

作　　者：周金云[1] 陈未名[1] 方起程[1] 

机构地区：[1]中国医学科学院,中国协和医科大学药物研究所,北京100050

出　　处：《Acta Botanica Sinica》2000年第1期1-9,共9页Acta Botanica Sinica（植物学报：英文版）

摘　　要：The paper reviewed the 13 CNMR features of natural taxane diterpenoids according to their carbonskeleton types. In the 13 CNMR it is easy to distinguish the 6/8/6 and 5/7/6 membered rings by observation of the 13 CNMR data of C1 and C15. The remarkable differences of the resonance of C13 and C12 were found. In addition, based on various chemical environments many obscured chemical shifts of carbons can be distinguished, such as the oxygenated tertiary carbons of C2, C5, C7, C9 and C13, and sometimes between C9 and C10, as well as between aliphatic quaternary carbons of C8 and C15, and secondary carbons of C6 and C14. All the abovementioned characteristics are helpful for structural elucidation and assignments of the carbon signals of taxoids.The paper reviewed the 13 C_NMR features of natural taxane diterpenoids according to their carbon_skeleton types. In the 13 C_NMR it is easy to distinguish the 6/8/6 and 5/7/6 membered rings by observation of the 13 C_NMR data of C_1 and C_15. The remarkable differences of the resonance of C_13 and C_12 were found. In addition, based on various chemical environments many obscured chemical shifts of carbons can be distinguished, such as the oxygenated tertiary carbons of C_2, C_5, C_7, C_9 and C_13, and sometimes between C_9 and C_10, as well as between aliphatic quaternary carbons of C_8 and C_15, and secondary carbons of C_6 and C_14. All the above_mentioned characteristics are helpful for structural elucidation and assignments of the carbon signals of taxoids.

关 键 词：天然紫杉烷类二萜 核磁共振 碳谱 抗肿瘤药物 

分 类 号：Q946[生物学—植物学]