应用单一抗菌药物患者出现多药耐药鲍氏不动杆菌感染分析  

Clinical study of multidrug-resistant Acinetobacter baumanniiinfections in patients treated with single antibiotics

作　　者：张瑞新[1] 赵攀[2] 管群[3] 

机构地区：[1]解放军第302医院药学部,北京100039 [2]解放军第302医院肝衰竭诊疗与研究中心,北京100039 [3]解放军第302医院感染控制科,北京100039

出　　处：《中华医院感染学杂志》2013年第11期2726-2727,共2页Chinese Journal of Nosocomiology

摘　　要：目的探讨抗菌药物应用与多药耐药鲍氏不动杆菌感染的关系,以指导临床合理用药。方法收集医院2011年1-12月确诊为多药耐药鲍氏不动杆菌感染,且确诊前采用单一抗菌药物治疗的住院患者资料进行分析。结果 23例患者中应用头孢菌素类9例占39.13%、碳青霉烯类6例占26.87%、青霉素类4例占17.39%、氟喹诺酮类4例占17.39%。结论头孢菌素类或碳青霉烯类单药治疗鲍氏不动杆菌易诱导其产生耐药。OBJECTIVE To study the relationship between the multi-drug resistant Acinetobacter baumannii infections and the administration of antibiotics so as to guide the reasonable use of antibiotics. METHODS The patients diagnosed as the multidrug-resistant A. baumannii infections were collected and treated with single antibiotics in the hospital from Jan to Dec 2011, and the clinical data of the hospitalized patients were analyzed. RESULTS Of totally 23 patients investigated, there were 9 （39. 13%） cases of patients who were treated with cephalosporins, 6 （26.87%） cases treated with carbapenems, 4 （17.39%） cases treated with penicillins, and 4 （17.39%） cases treated with fluoroquinolones. CONCLUSION The single use of cephalosporins or carbapenems is prone to induce the drug resistance of A. baumannii.

关 键 词：鲍氏不动杆菌 抗菌药物 耐药 感染 

分 类 号：R978.1[医药卫生—药品]