不对称转化法制备D-甲硫氨酸  

Preparation of D-methionine by asymmetric transformation

作　　者：廖本仁[1,2] 詹家荣 

机构地区：[1]华东师范大学化学系,上海200062 [2]上海化学试剂研究所,上海200333

出　　处：《化学试剂》2013年第6期558-560,共3页Chemical Reagents

摘　　要：以L-甲硫氨酸为原料,3-溴-5-氯水杨醛为消旋催化剂,D-二对甲基苯甲酰酒石酸为拆分剂,在甲醇溶液中实现L-甲硫氨酸不对称转化制备得到D-甲硫氨酸,单程收率>80%,光学纯度>99%。D-Methionine was obtained by the asymmetric transformation of L-methionine in methanol,with racemization catalyst such as 3-bromo-5-chlorosalicylaldehyde, with a resol- ving agent such as （ ＋ ）-O, O＇-Di-p-toluoyl-D-tartaric acid. Under the optimized conditions, the yield reached to more than 80% with the optical purity to 99%.

关 键 词：L-甲硫氨酸 不对称转化 D-甲硫氨酸 

分 类 号：O622.5[理学—有机化学]