以氰基乙醛为中间体合成吡唑类化合物  

Synthesis of 5-aminopyrazoles mediated by cyanoacetal-dehyde

作　　者：姚鹏[1] 

机构地区：[1]新乡学院化学与化工学院,河南新乡453000

出　　处：《化学试剂》2013年第6期570-572,共3页Chemical Reagents

摘　　要：以乙腈、乙醇钠和CO气体为原料,高压反应得到3-羟基丙烯腈的钠盐,中和得到氰基乙醛的溶液。氰基乙醛的溶液直接和肼反应,得到5-氨基吡唑类化合物,收率68%～85%。反应原料廉价易得,具有很高的原子经济性,符合绿色化学的要求,具有潜在的应用前景。The synthesis of sodium salt of cyanoacetaldehyde was carried out using acetonitrile,sodium ethoxide and carbon monoxide through high-pressure reaction. The salt was neu- tralized to give a solution of cyanoacetaldehyde. The 5-amin- opyrazoles was synthesized by the reaction of cyanoacetalde- hyde with hydrazines in 68% ~ 85% yield. The advantages of this method are available materials, high atom economy and meeting the requires of green chemistry, showing potential ap- plication prospect.

关 键 词：氰基乙醛 吡唑 肼 原子经济性 

分 类 号：O626.32[理学—有机化学]