左氧氟沙星单用及联用双黄连后兔组织液中的浓度差异  

Levofloxacin concentration in rabbit tissue cage model with Levofloxacin used alone or combined with Shuanghuanglian injection

作　　者：王国俊[1] 叶云[1] 龙恩武[2] 李虹[3] 韩彬[3] 

机构地区：[1]泸州医学院附属医院药剂科,四川泸州646000 [2]四川省医学科学院四川省人民医院药剂科,四川成都610072 [3]泸州医学院药学院,四川泸州646000

出　　处：《华西药学杂志》2013年第3期269-271,共3页West China Journal of Pharmaceutical Sciences

基　　金：杨森科学研究委员会中国分会研究基金资助项目(JRCC2011药理02);2009年泸州市科技计划项目(泸市科[2009]72号)

摘　　要：目的探讨左氧氟沙星单用及联用双黄连兔后,织液中左氧氟沙星的浓度差异。方法建立兔组织笼感染模型,采用左氧氟沙星单用及左氧氟沙星联用双黄连治疗,HPLC法测定兔组织笼内左氧氟沙星浓度。结果左氧氟沙星联用双黄连后兔组织液中左氧氟沙星浓度与单用时无显著性差异。结论双黄连与左氧氟沙星联用不影响左氧氟沙星在感染部位的浓度。OBJECTIVE To study the difference of Levofloxacin concentration in rabbit tissue cage model with Levofloxacin（Lev） used alone or combined with Shuanghuanglian.METHODS Lev was used alone or combined with Shuanghuanglian to rabbit.Lev concentration in rabbit tissue cage model were determined by HPLC.RESULTS There were no significant differences in concentration of two groups.CONCLUSIONS Shuanghuanglian combined with Lev has no effect on Lev concentration in infection site.

关 键 词：浓度 左氧氟沙星 双黄连注射液 联用 

分 类 号：R917[医药卫生—药物分析学]