补骨脂酚平衡溶解度和表观油水分配系数的测定  

Determination of equilibrium solubility and apparent oil/water partition coefficient of bakuchiol

作　　者：高旭[1] 于悦[1] 王亚静[1] 皮佳鑫[1] 张伟玲[1] 轩肖玉[1] 

机构地区：[1]天津中医药大学天津市现代中药重点实验室-省部共建国家重点实验室培育基地,天津300193

出　　处：《华西药学杂志》2013年第3期285-286,共2页West China Journal of Pharmaceutical Sciences

基　　金："重大新药创制"科技重大专项(2012ZX09103201-046;2012ZX09101212)

摘　　要：目的测定补骨脂酚的平衡溶解度及其在正辛醇-水/缓冲液体系中的表观油水分配系数,为补骨脂酚的剂型设计提供依据。方法采用HPLC测定补骨脂酚在不同pH介质中的平衡溶解度及其在正辛醇-水/缓冲液体系中的表观油水分配系数P。结果 37℃时补骨脂酚在水中的平衡溶解度为0.86±0.19 mg.L-1,pH7.4缓冲液中平衡溶解度为1.35±0.30 mg.L-1。37℃时补骨脂酚的logP为4.27±0.08。结论补骨脂酚为溶解度小的亲脂性药物,不同pH下P变化不大。OBJECTIVE To determine the equilibrium solubility of bakuchiol and its apparent oil/water partition coefficients in the noctanol-water/buffer solution systems for dosage form design.METHODS An HPLC method was used to detect the concentration of bakuchiol in water and the partition coefficients in the n-octanol-water/buffer solution systems.RESULTS The equilibrium solubility of bakuchiol in water was 0.86±0.19 mg·L^-1 at 37 ℃ and when pH7.4,the equilibrium solubility reached amaximum 1.35±0.30 mg·L^-1.1ogP of bakuchiol was 4.27±0.08 at 37 ℃.CONCLUSION Bakuchiol is a lipophilic drug with bad water solubility.The pH has little impact on the apparent oil/water partition coefficient of bakuchiol.

关 键 词：补骨脂酚 平衡溶解度 表观油水分配系数 高效液相色谱法 

分 类 号：R917[医药卫生—药物分析学]