炎性基因与环境交互作用及胃癌易感性分析  

Inflammatory cytokine gene-environment interaction on risk of gastric cancer susceptibility

作　　者：高丽君[1] 宋春花[1] 李海霞[1] 冯云霞[1] 曹小琴[1] 崔姝沥[1] 代丽萍[1] 张建营[1] 王凯娟[1] 

机构地区：[1]郑州大学公共卫生学院流行病与卫生统计学教研室河南省肿瘤流行病学重点实验室,河南郑州450001

出　　处：《中国公共卫生》2013年第6期799-801,共3页Chinese Journal of Public Health

基　　金：国家自然科学基金(30972547)

摘　　要：目的探讨胃癌患病风险的炎性基因白介素1(IL-1)、肿瘤坏死因子(TNF)及巨噬细胞转移抑制因子(MIF)与环境间交互作用。方法用多因子降维法(MDR)模型分析基因-环境的交互作用对胃癌易感性影响,结合logistic回归分析进行补充验证。结果最佳交互作用模型是IL-1B-511、IL-1RN、TNF-A-308和肿瘤家族史的联合作用(P<0.01),交叉验证一致性10/10,检验样本准确度为0.72;根据模型将研究对象划分为高危、低危人群,胃癌发病风险交互效应的危险度估计OR=13.49,95%CI=8.62～21.10,且交互作用有统计学意义(P<0.01);将危险因素按结合数量进行分析,结果显示含有1、2、3个危险因素组在病例和对照中分布差异均有统计学意义(P<0.05),OR值分别为2.17、11.61、27.19。结论 IL-1B-511、IL-1RN、TNF-A-308和肿瘤家族史的交互作用可能增加胃癌患病风险。Objective To explore the application of multifactor dimensionality reduction（MDR） in the risk assessment of inflammatory cytokine gene（interleukin-1,tumor necrosis factor and macrophage migration inhibitory factor）-environment interaction in gastric cancer research.Methods The MDR software was applied to analyze gene-environment interaction on the risk of gastric cancer susceptibility,while the results of logistic regression was analysed as supplement.Results The interaction among IL-1B-511,IL-1RN,TNF-A-308 genotypes and tumor familial history made the best MDR model with a statistical significance（P 0.01）.Testing balance accuracy of this model was 0.72 and the cross-validation consistency was 10/10.The research subjects were divided into ＂high-risk＂ and ＂low-risk＂ groups according to this model.The estimated odds ratio（OR） value of interaction effects on gastric cancer was 13.49（95%confidence interval ：8.62-21.10） with a statistical significance（P〈0.01）.There were significant differences among group 1（one factor）,group 2（two factors） and group 3（three factors）（P〈0.05） with the OR values of 2.17,11.61,and 27.19.Conclusion The interaction of IL-1B-511,IL-1RN,TNF-A-308 and tumor familial history may increase the risk of gastric cancer.

关 键 词：多因子降维法(MDR) 基因-环境交互作用 胃癌 

分 类 号：R181[医药卫生—流行病学]