高血压合并糖代谢异常高危人群多重心血管危险因素患者中医证候研究  

Study on TCM Syndromes of Patients with Multiple Cardiovascular Risks and Hypertension with Abnormal Glucose Metabolism

作　　者：胡珍[1] 王亚红[1] 陈旸[1] 王文哲[1] 朱文秀[1] 王硕仁[1] 郭维琴[1] 

机构地区：[1]北京中医药大学东直门医院心血管科中医内科学教育部重点实验室(北京中医药大学)北京市普通高校重点实验室(中医内科学),北京100700

出　　处：《中华中医药学刊》2013年第6期1327-1329,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：北京市中医药薪火传承"3+3工程"郭士魁名家研究室项目(2011-SZ-A-27);郭维琴名医传承工作站项目(2011-SZ-C-33);首发基金联合攻关资助项目(SF-2009-I-04)

摘　　要：目的:分析高血压合并糖代谢异常高危人群的中医证候分布特点,为中医早期干预提供依据。方法:将高血压病合并血糖异常的高危患者53例,采集多重危险因素信息和中医证候,进行临床流行病学的随机、对照、横断面研究,分析高血压病合并血糖异常高危人群的非急性事件组与急性事件组的中医证候和多重危险因素分布、发生急性心血管事件与否的中医证候logistic回归分析。结果:①急性事件组风证的发生百分率高于非急性事件组,存在显著性差异(P﹤0.05);②对中医证候逐步logistic回归分析提示风证、痰证与急性事件发生密切相关,回归方程为:logit(P)=-0.334+1.595*风证+1.823*痰证-1.519*肝虚。结论:风证、痰证为急性缺血性心血管事件的发病的中医实证病机。Objective ： Following the methods and principles of clinical epidemiology, this paper analyzed TCM syndromes of high - risk patients with multiple cardiovascular risk factors to provide the basis for Chinese medicine early intervention. Methods ：The target was high risk population of hypertension with abnormal glucose metabolism in both clinic and ward of cardiovascular department of Dongzhimen Hospital of Beijing University of Chinese Medicine from April 2011 to April 2012. On the basis of investigating epidemiology., the different means was used to collect multiple risk factors and related Chinese medicine syndrome,53 systemic investigated cases aged between 35 and 85 years old were chosen and the average age was （63.02 ± 9.73 ） years old. The statistical methods, such as T test, Chi - Square, regression analysis, partial correlation analysis and so on were used. The diagnosis standard of Chinese medicine which is enact by national Chinese medicine was used. We studied the distribution of TCM syndrome of patients with multiple risk factors for cardiovascular disease and the distribution of multiple risk factors of different syndromes. Results ： （1） TCM syndrome distribution of non - acute event group（ including the high - risk group and very high - risk group） and the acute event group basically consistent with that of the overall high - risk groups. There were significant differences of wind syndrome between non - acute event group and the acute event group（P 〈 0.05）. （2）Logistic regression analysis showedthat there was significant correlation with wind syndrome, phlegm syndrome and acute ischemic cardiovascular events, the regression equation was logit（P） = -0.334 ± 1. 595 ＊ wind syndromel. 823 ＊ phlegm syndrome- 1. 519 ＊ liver deficiency syndrome. Conclusions ： Chi - Square and Logistic regression analysis show that phlegm syndrome and wind syndrome are significantly associated with acute ischemic cardiovascular events.

关 键 词：多重危险因素 高血压 糖代谢异常 中医证侯 

分 类 号：R259.441[医药卫生—中西医结合]