RNA干扰介导的抗HIV治疗研究进展  

Research Progress of Anti-HIV Therapy Mediated by RNAi

作　　者：杨文思[1] 王沂[2] 王洋[3] 

机构地区：[1]河北大学生命科学学院,保定071000 [2]河北联合大学附属医院,唐山063000 [3]河北联合大学生命科学学院,唐山063000

出　　处：《生物技术通报》2013年第5期28-33,共6页Biotechnology Bulletin

基　　金：河北青年科学基金项目(C2012401039)

摘　　要：人类免疫缺陷病毒(HIV)是引起获得性免疫缺陷综合征(AIDS)的病原体,即艾滋病,目前尚无有效的治愈方法,严重危害着人类的健康。RNA干扰(RNAi)是一种由双链RNA所引起的序列特异性基因沉默,被广泛应用于生物医学研究。目前,已经有多个研究机构将RNAi作为对抗HIV感染的可行手段并通过试验进行了验证,其采取的方法主要包括靶向siRNA治疗和载体介导的shRNA治疗。就HIV RNAi治疗的研究现状作一综述。Human immunodeficiency virus（HIV）is the pathogen of Acquired Immune Deficiency Syndrome（AIDS）,which is an incurable disease and has become a serious public health problem.RNA interference（RNAi）is a post-transcriptional process triggered by the introduction of double-stranded RNA（dsRNA）which leads to gene silencing in a sequence-specific manner.RNAi technology has been widely used in biological and medical research.At present,many researchers have taken RNAi technology as a possible anti-HIV method and tested it in experiments.The main means in RNAi mediated anti-HIV experiments included siRNA targeted therapy and shRNA plasmid mediated therapy.This article will review the research progress of anti-HIV therapy mediated by RNAi.

关 键 词：HIV RNAI siRNA SHRNA 靶向治疗 适体 慢病毒载体 

分 类 号：R512.91[医药卫生—内科学]