对甲基桂皮丹酚酯抗辐射活性的研究  

Protective effect of P-methyl cinnamic paeonol esters against radiation damage

作　　者：白佳利[1] 于程程[1] 王德芝[1] 沈秀[1] 郝建秀[1] 王浩[1] 龙伟[1] 周则卫[1] 

机构地区：[1]北京协和医学院中国医学科学院放射医学研究所,天津市分子核医学重点实验室, 天津300192

出　　处：《国际放射医学核医学杂志》2013年第3期139-142,共4页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金（81202153）;北京协和医学院青年基金（2012D03）;中国医学科学院放射医学研究所学科发展基金（SF1227）;教育部博士点新教师基金（20121106120042）

摘　　要：目的研究对甲基桂皮丹酚酯的抗辐射活性。方法以6～8周龄的ICR小鼠作为研究对象，经137Cs γ射线一次性全身照射后，以30d存活率、血液生化指标、脏器指数及肺和肝的超氧化物歧化酶（SOD）、丙二醛为指标，考察低、中、高3个剂量组的对甲基桂皮丹酚酯的抗辐射损伤效应。结果对甲基桂皮丹酚酯可以提高经8．5GyGy137Cs γ射线一次性全身照射损伤ICR小鼠的30d存活率，对小鼠经6．5Gy137Cs γ射线一次性全身照射损伤生理指标影响的检测结果显示，对甲基桂皮丹酚酯在不同程度上提高了血小板和DNA含量、胸腺指数和脾脏指数；且SOD水平随着对甲基桂皮丹酚酯剂量的增加而增加，而丙二醛水平则有所降低，尤其是高剂量组的效果较显著。结论对甲基桂皮丹酚酯可能具有抗辐射损伤作用。Objective To study the radiaition protective effect of P-methyl cinnamic paeonol esters on irradiated mice. Methods ICR mice of age 6-8 weeks were selected as investigated sub- jects, then the mice whole body were irradiated with 6.5 Gy or 8.5 Gyt37Cs ＂y-ray. The 30-day sur- vival rates, organ indexes, superoxide dismutase （SOD）and malondialdehyde levels in lung and liver were observed to evaluate the radiation protective effect of P-methyl cinuamic paeonol esters in high, medium, low dose groups. Results P-methyl einnamic paeonol esters increased the 30-day survival rates of 8.5 Gy whole body irradiated mice. And after 6.5 Gy whole body irradiation, P-methyl cin- namic paeonol esters could enhance the platelet counts, DNA levels and thymus, spleen index. Meanwhile, SOD levels were increased with the increasing dose of P-methyl einnamic paeonol esters, while malondialdehyde levels were decreased, especially in the high dose group. Conclusion P- methyl cinnamie paeonol esters may play an important role in radiation resistance.

关 键 词：辐射耐受性 铯放射性同位素 对甲基桂皮丹酚酯 

分 类 号：R285.5[医药卫生—中药学]