阻塞性睡眠呼吸暂停低通气综合征患者血清和呼出气冷凝液中基质金属蛋白酶-2的水平及意义  

The levels and meaning of matrix metalloproteinase-2 in serum and exhaled breath condensate of patients with obstructive sleep apnea hypopnea syndrome

作　　者：朱建勇[1] 曾玉琴[2] 邝军[1] 陈功[1] 张立波[1] 王永兰[1] 

机构地区：[1]湖北医药学院附属人民医院呼吸内科,十堰442000 [2]湖北医药学院附属太和医院内分泌科,十堰442000

出　　处：《国际呼吸杂志》2013年第11期830-833,共4页International Journal of Respiration

基　　金：湖北医药学院研究生启动基金资助（2010QDJ35）

摘　　要：目的探讨血清和呼出气冷凝液（EBC）中基质金属蛋白酶-2（MMP2）的水平与阻塞性睡眠呼吸暂停低通气综合征（OSAHS）发病的关系。方法利用酶联免疫吸附法对30例轻度OSAHS患者（轻度OSAHS组）、68例中重度OSAHS患者（中重度OSAHS组）和22名健康者（正常对照组）血清及EBC中MMP-2的水平进行检测，对其中40例中重度OSAHS患者在持续气道正压通气（CPAP）治疗1个月后进行复查。结果与正常对照组相比，轻度、中重度OSAHS患者血清及EBC中MMP2的水平依次增高，40例中重度OSAHS患者在CPAP治疗后明显下降，差异具有统计学意义（t=2．369、2．512，P值均〈0．05）。结论OSAHS患者血清及EBC中MMP-2水平升高，与OSAHS的发病可能相关。Objective To explore the relation between the levels of matrix metalloproteinase-2 （MMP-2） in serum and exhaled breath condensate （EBC） and obstructive sleep apnea-hypopnea syndrome （OSAHS）. Methods Thirty patients with mild OSAHS （mild OSAHS group） ,sixty-eight patients with middle-severe OSAHS （middle-severe OSAHS group）, and twenty-two healthy adults （control group） were collected, the levels of MMP-2 in their serum and EBC were detected with ELISA. They were detected again in the forty patients from the middle-severe group after treated with continuous positive airway pressure （CPAP） for 1 month. Results In the mild and middle-severe OSAHS groups the levels of MMP-2 in serum and EBC were significantly higher than those of the control group, there was a significant decrease in the 40 patients from the middle-severe OSAHS group after treated with CPAP for 1 month （ t = 2. 369,2. 512, P M0.05）. Conclusions The levels of MMP-2 in serum and EBC of patients with OSAHS was higher,it may be involved with OSAHS.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 血清 呼出气冷凝液 基质金属蛋白酶-2 

分 类 号：R766[医药卫生—耳鼻咽喉科]