氟砜霉素的急性毒性和亚慢性毒性试验  

Acute and Subchronic Toxicity of Florfenicol on Rats

作　　者：杨桂香[1] 邓国东[1] 邹明 曾振灵[1] 陈杖榴[1] 

机构地区：[1]华南农业大学动物医学系,广东广州510642

出　　处：《中国兽医学报》2000年第3期275-278,共4页Chinese Journal of Veterinary Science

摘　　要：氟砜霉素对大鼠的急性毒性试验结果表明 ,氟砜霉素对大鼠的经口 LD5 0 大于每千克体重 50 0 0 mg。亚慢性毒性试验的结果表明 ,按每千克体重 1 0 0 mg的剂量应用氟砜霉素 3 0 d以上 ,会减少大鼠的增重 ,降低骨髓的造血机能 ,损伤肝脏 ,严重损伤肾脏及睾丸 ,但对脾脏、肺脏、雌性生殖器官、大脑无损伤。氟砜霉素 50mg/ kg的剂量对肾脏有轻度的损伤 ,在 3 0 d时可减少大鼠的增重 ,但对其他组织器官以及骨髓造血机能均无影响。氟砜霉素 3 0 mg/ kg的剂量应用 60 d,对大鼠的增重。The acute and subchronic toxicity of florfenicol were studied on rats. The oral LD 50 of florfenicol was more than 5 000 mg/kg body weight. After exposure to rats over 30 days, florfenicol (100 mg/kg) could decrease weight gain, depress the activity of marrow hemogenesis and severely damage the kidney, testicle and liver, but had no obvious damage on the spleen, lung, female genitalia and brain. After exposure to rats over 30 days, florfenicol (50 mg/kg) could decrease weight gain, slightly damage rat′s kidney, but had no other side effects on rats. Florfenicol (30 mg/kg) had no appreciable side effects on rats after exposure to rats over 60 days.

关 键 词：氟砜霉素 亚慢性毒性 急性毒性 大鼠 抗菌素 

分 类 号：S859.796[农业科学—临床兽医学]