星点设计-效应面法优化32.5%苯醚甲环唑·嘧菌酯泡腾片剂配方  

The 32.5% difenoconazole-azoxystrobin effervescent tablet optimized by central composite design-response surface method

作　　者：喻湘林[1] 杨琛[2] 朱锐[1] 任璐[1] 王宁宁[1] 李晓刚[1] 

机构地区：[1]湖南农业大学生物安全科学技术学院,湖南长沙410128 [2]吉首市农业局,湖南吉首416000

出　　处：《湖南农业大学学报（自然科学版）》2013年第3期323-326,共4页Journal of Hunan Agricultural University(Natural Sciences)

基　　金：湖南省科技厅项目(2012NK4018);长沙市科技局项目(K1104013-21)

摘　　要：应用星点设计-效应面法对32.5%苯醚甲环唑·嘧菌酯泡腾片剂配方进行优化,以分散剂、崩解剂和起泡剂用量为考察因素,以片剂悬浮率和崩解时间为考察指标,采用多元非线性回归拟合选择合适模型,依据模型在各因素设定范围内获得最佳配方为:分散剂WG5质量分数为4.75%,分散剂TXC质量分数为1.50%,崩解剂聚乙烯吡咯烷酮PVPP质量分数为5.00%,起泡剂酒石酸和碳酸氢钠质量分数均为20%,该条件下进行3次重复试验,结果表明,片剂实际平均悬浮率为86.42%,平均崩解时间为159 s,与预测值86.14%和160 s无显著差异。The aims of the present study are to exam the dispersing agent, disintegrating agent and blowing agent, based on the index of tablet suspension rate and disintegration time. The data is simulated by using multi-nolinear equation to select proper model. The best formulations based on the factors within setting ranges are： WG5（4,75%）, TXC（1.50%）, PVPP（5.00%）, foaming agent（40%）.Three times of repeated experiments showed that the average rate of suspension was 86.42%, disintegration time was 159 s, almost equal to the predictions： 86.14% and 160 s.

关 键 词：苯醚甲环唑 嘧菌酯 泡腾片剂 星点设计-效应面法 

分 类 号：TQ450.45[化学工程—农药化工]