首发重性抑郁症患者家庭功能与疗效的相关性  

The correlation between family function and the therapeutic effect in the patients with first-episode major depressive disotder

作　　者：申景进[1] 陈向一[1] 黄国平[2] 

机构地区：[1]广东医学院附属南山医院,518052 [2]四川省精神卫生中心

出　　处：《四川精神卫生》2013年第2期78-81,共4页Sichuan Mental Health

基　　金：国家科技支撑计划项目(2009BAI77B05)

摘　　要：目的探讨首发重性抑郁症患者治疗效果与患者家庭功能的关系,为重性抑郁症患者的干预提供理论依据和实践指导。方法采用前瞻性设计,用家庭环境量表(中文版)(FES-CV)对66例首发重性抑郁症患者进行基线期评估,在基线、治疗2周末和6周末同用汉密尔顿抑郁量表-17(HAMD-17)和临床总体印象量表(CGI)进行评估。结果痊愈组家庭的亲密度、情感表达和组织性因子分高于未痊愈组,矛盾性和控制性因子分低于未痊愈组,差异有统计学意义(P均<0.05或0.01)。家庭的亲密度、情感表达、独立性、成功性和娱乐性因子分与HAMD6周末总分减分率正相关,控制性因子分与6周末总分减分率负相关,差异有统计学意义(P均<0.05或0.01)。结论重性抑郁症患者家庭功能与治疗效果有关,改善患者的家庭功能可能有助于提高疗效。Objective Investigating the correlation between family function and therapeutic effect in patients with First - episode major depressive （ MDD）, and providing theoretical basis and practical guidance. Methods Family Environment Scale - Chinese Version（ FES - CV） was administered to 66 MDD patients at the baseline. Hamilton Rating Scale for Depression （HAMD） and Clinical Global Impression （CGI） were administered at the baseline,the 2th and 6th week after treatment, respec- tively. Results Compared to the non -remission group＇s families, families in clinical remission group with significantly higher scores in cohesion, expressiveness and organization （ P 〈 0. 05 ） and lower scores in contrary factor and control factor （ P 〈 0. 05 ）. The reduction rate of HAMD scores at the end of 6^th week were positively correlated with scores in cohesion, feeling expression, independence, achievement and entertainment （P 〈 0. 05 ）, and negatively correlated with scores in control factor （ P 〈 0. 05 ）. Conclusion The efficacy of antidepressant treatment of first - episode major depressive disorder associated family function, and improving family function could help improving DMM patients＇outcome.

关 键 词：重性抑郁症 家庭功能 相关性 疗效 前瞻性 

分 类 号：R794[医药卫生—临床医学]