无抽搐电休克与氟哌啶醇针剂治疗急性期精神分裂症的对照研究  

A comparative study of the effect of modified electroconvulsive therapy and haloperidolin injection on patients with a-cute phase schizophrenic

作　　者：陈一郡[1] 宋兵福[1] 伍毅[1] 

机构地区：[1]上海市杨浦区精神卫生中心,200090

出　　处：《四川精神卫生》2013年第2期100-102,共3页Sichuan Mental Health

摘　　要：目的比较无抽搐电休克(MECT)与氟哌啶醇针剂对急性期精神分裂症的疗效和安全性。方法采用数字随机法将90例急性期精神分裂症患者分成MECT组和氟哌啶醇组,疗程为1周,分别在治疗前、治疗后1、3和7天末采用阳性与阴性症状量表(PANSS)评定疗效,用副反应量表(TESS)和韦氏记忆量表(WMS)评定不良反应。结果治疗结束后,MECT组显效率为59.10%,有效率90.90%;氟哌啶醇组显效率为55.80%,有效率88.40%,两组间差异无统计学意义(P>0.05)。治疗后两组患者的PANSS总分和阳性症状因子分较治疗前均降低(P<0.05),在治疗后第3天和第7天末MECT组的PANSS总分和阳性症状因子分均低于氟哌啶醇组(P<0.05)。治疗结束时MECT组WMS总分较治疗前降低(P<0.05),但至2周已完全恢复到治疗前水平(P>0.05)。不良反应发生率,MECT组低于氟哌啶醇组,两组差异有统计学意义(P<0.01)。结论 MECT对急性期精神分裂症的治疗是有效而安全的,值得在临床中应用。Objective To compare the effect and safety of modified electroconvulsive therapy （MECT） and haloperidolin injection in treating patients with acute phase schizophrenia. Methods Ninety acute phase sehizoprenia patients were randomly divided into MECT group and haloperidol group. All the patients were evaluated with the positive and negative syndrome scale （PANSS）, the treatment emergent symptoms scale（TESS） and the wechsler memory scale（ WMS ）before treatment and at the 24 hour, 72hour and lweek after treatment. Results At the end of the lthweek, excellence and total effective rate were 59.10% and 90.90% in research group and 55.80% and 88.40% in control group （ P 〈 0.01 ） ;There was temporary effect on memory of such patient treated with MECT （P 〈 0.05 ） however it would recover after about 2 weeks at end of treatment. Conclusion MECT is effective and safe in the treatment patients with acute schizophrenic. And it is valuable to be recommended clinically.

关 键 词：MECT 氟哌啶醇针剂 精神分裂症 

分 类 号：R794.3[医药卫生—临床医学]