膏方外源性有害残留物的监控  

Monitoring of extrinsic harmful residues in herbal paste

作　　者：郑敏霞[1] 沈洁[1] 王胜波[2] 朱涛[2] 

机构地区：[1]浙江中医药大学附属第一医院,浙江杭州310006 [2]浙江中医药大学中药炮制技术中心,浙江杭州311401

出　　处：《中草药》2013年第10期1280-1285,共6页Chinese Traditional and Herbal Drugs

基　　金：浙江省教育厅丹参注射液含药血清谱与血管保护作用的谱效研究(Y200906846);浙江省中医管理局"冬病夏治"贴膏的研制及质量评价研究(2010ZJ001)

摘　　要：目的对膏方中农药残留和重金属残留进行监测,以期为膏方全面质量控制提供依据。方法采用GC法测定膏方中六六六(BHC,含α-BHC、β-BHC、γ-BHC、δ-BHC)、滴滴涕(DDT,含PP′-DDE、PP′-DDD、OP′-DDT、PP′-DDT)和五氯硝基苯(PCNB)的量;采用原子吸收光谱法测定Pb、Cd、As、Hg、Cu的量。结果 4批次膏方中的农药残留:BHC和DDT总量低于20 ng/g,PCNB的量低于10 ng/g;重金属残留:Pb的量低于0.5μg/g,Cd的量低于30 ng/g,As和Hg的量低于0.2μg/g,Cu的量低于2μg/g。结论膏方中农药残留量和重金属残留量均符合《中国药典》和欧盟规定的限量标准。Objective To monitor the pesticide residues and heavy metal residues in the herbal paste and to provide the basis for the total quality control of the herbal paste.Methods The contents of benzene hexachloride（BHC,containing α-BHC,β-BHC,γ-BHC,and δ-BHC）,dichloro-diphenyl-trichloroethane（DDT,containing PP′-DDE,PP′-DDD,OP′-DDT,and PP′-DDT）,and pentachloronitrobenzene（PCNB） were determined by using the method of gas chromatography.The contents of Pb,Cd,As,Hg,and Cu were determined by using atomic absorption spectrometry.Results Pesticide residues in four batches of the herbal paste were as follows： The total BHC and DDT were less than 20 ng/g,and PCNB was less than 10 ng/g.The heavy metal residues were as follows： Pb was less than 0.5 μg/g,Cd was less than 30 ng/g,As and Hg were less than 0.2 μg/g,and Cu was less than 2 μg/g.Conclusion Pesticide residues and heavy metal residues in the herbal paste accord with the limit standards of Chinese Pharmacopoeia and the EU rules.

关 键 词：农药残留 重金属残留 膏方 GC法 原子吸收光谱法 

分 类 号：R286.02[医药卫生—中药学]