272例高原地区肺动脉高压病中血清肌钙蛋白Ⅰ及血红蛋白水平分析  

Changes on Serum Level of Troponin-Ⅰin 272 Cases of Pulmonary Hypertension at High Altitude

作　　者：袁汶[1] 

机构地区：[1]青海省人民医院检验科,810007

出　　处：《青海医药杂志》2013年第2期11-13,共3页Qinghai Medical Journal

摘　　要：目的:通过对高原肺动脉高压病血清肌钙蛋白Ⅰ(CTnⅠ)、血红蛋白(Hb)水平分析,探讨高原肺动脉高压病与血清肌钙蛋白I(CTnⅠ)、Hb的相关性。方法:采用美国Beckman公司生产的ACCESS全自动微粒子化学发光免疫分析仪,夹心ELAISA法定量测定血清CTnⅠ;使用日本希森美康公司生产的XE2100全自动血细胞分析仪测定Hb。结果:本研究健康人血清CTnⅠ测定结果为(0.61±0.10)ng/mL,Hb(142±15.7)g/L;高原肺动脉高压病人群CTnⅠ为(1.44±0.16)ng/mL,Hb(188±10.3)g/L,两组比较差异非常显著,具有统计学意义(P<0.01)。结论:高原肺动脉高压病人群血清CTnⅠ、Hb含量明显升高,为进一步预防、诊治高原肺动脉高压病提供参考依据。Objective：To observe the changes on serum level of cardiac troponin - I （ CTn - I ） in patients with hypoxic pulmonary hypertension, and to explore the correlation between hypoxic pulmonary hypertension and serum CTn -! at high altitude. Methods：This study was consisted of 50 healthy control objects and 272 cases of hypoxic pulmonary hypertension; they were free to COPD, coronary disease and other heart and lung disease. The level of CTn - 1 was detected by ELSIA method using ACCESS automated chemiluminescent immunoassay system made in USA. Results： Serum level of CTn - I in control group and pulmonary hypertension group was （0.61 ± 0. 10）ng/mL and（ 1.44 ± 0.16） ng/mL respectively, and Hb level was （ 142 ± 15.7 ） g/L and （ 188 ± 10.3 ） g/L respectively, there was a significant difference between the both groups （ P 〈 0.05 ）. Conclusions： Level of CTn - I is obviously increased in the cases of pulmonary hypertension; the result contributes to diagnosis and treatment of pulmonary hypertension at high altitude.

关 键 词：肺动脉高压病 肌钙蛋白Ⅰ 血红蛋白 

分 类 号：R339.54[医药卫生—人体生理学] R446.11[医药卫生—基础医学]