STUDIES ON THE DEGRADATION OF POLY(L-LACTIDE-r-TRIMETHENE CARBONATE) COPOLYMERS  

作　　者：Yuan-lin Li Sai Li Li-jie Ji Bin He 顾忠伟 

机构地区：[1]School of Chemical Engineering,Sichuan University [2]National Engineering Research Center for Biomaterials,Sichuan University

出　　处：《Chinese Journal of Polymer Science》2013年第7期966-973,共8页高分子科学（英文版）

基　　金：financially supported by the National Basic Research Program of China (National 973 program,No. 2011CB606206);the National Natural Science Foundation of China (Nos. 50830105, 51133004);Program for New Century Excellent Talents in Universities, Ministry of Education (MOE, NCET-10-0564);Program for Changjiang Scholars and Innovative Research Teams in Universities (IRT1163)

摘　　要：Biodegradable poly（L-lactide-r-trimethene carbonate） copolymers （P（LLA-co-TMC）） with different compositions were synthesized. The degradation of the copolymers was carried out in phosphate buffer saline solutions （pH = 7.4） at 37℃. The compositions, structure and properties of the copolymers in degradation were characterized with IH-NMR, DSC, XRD, GPC, and SEM. The weight loss of the P（LLA-co-TMC） 50/50 was much faster than that of P（LLA-co-TMC） 85/15 and PLLA homopolymer. Interestingly, though the molecular weight of the compolymers decreased greatly during degradation, the compositions were rarely varied. After long time degradation, the PLLA segments were induced to crystallize in the P（LLA-co-TMC） 85/15 copolymer. The SEM observation of the surface and cross-section of P（LLA-co- TMC） 85/15 copolymer films found it was similar to the bulk degradation of PLLA homopolymer.Biodegradable poly（L-lactide-r-trimethene carbonate） copolymers （P（LLA-co-TMC）） with different compositions were synthesized. The degradation of the copolymers was carried out in phosphate buffer saline solutions （pH = 7.4） at 37℃. The compositions, structure and properties of the copolymers in degradation were characterized with IH-NMR, DSC, XRD, GPC, and SEM. The weight loss of the P（LLA-co-TMC） 50/50 was much faster than that of P（LLA-co-TMC） 85/15 and PLLA homopolymer. Interestingly, though the molecular weight of the compolymers decreased greatly during degradation, the compositions were rarely varied. After long time degradation, the PLLA segments were induced to crystallize in the P（LLA-co-TMC） 85/15 copolymer. The SEM observation of the surface and cross-section of P（LLA-co- TMC） 85/15 copolymer films found it was similar to the bulk degradation of PLLA homopolymer.

关 键 词：COPOLYMER Poly（L-lactide-r-trimethene carbonate） DEGRADATION Crystallization. 

分 类 号：O631.3[理学—高分子化学]