甘肃省成县黄渚乡地方性克汀病的临床研究  

Clinical Investigation of Endemic Cretinism in a Community in Gansu Province

作　　者：高林[1] 汤文章 吴纬[1] 刘永明[1] 赵萍[1] 张俊[1] 李涛[1] 闫升 薛如璇 薛荣 

机构地区：[1]兰州医学院第一附属医院内分泌科 [2]兰州市白银公司第二职工医院

出　　处：《地方病通报》1991年第1期66-69,共4页Endemic Diseases Bulletin

摘　　要：本文报道对地方性克汀病患者进行了临床神经病学检查,包括传统的椎体神经系统检查,而且注意检查了椎体外系统,特别对智力功能做了比较精细的研究。同时观察了垂体甲状腺功能,结果表明克汀病组血清T_4值较正常对照组低而TSH值高(P<0.05)。血清hGH空腹值两组无差别,但用左旋多巴兴奋后60分钟及90分钟值克汀病组低于正常对照组(P<0.05)。运用左旋多巴刺激试验证实地方性克汀病人垂体人类生长激素储备功能差,是一个新发现,有利于对碘缺乏病史深入地研究。Combined with the determination of pituitary and thyroid functions, neuro-pathological examinations were performed on patients with endemic cretinism in Huangzhu Community, Gansu Province. Results showed that average serum T4 in cretinist patients was lower and TSH higher than those in normal controls (P<0.05). No difference in fasting serum hGH was found between the 2 groups, however, serum hGH in cretinist patients was significantly lower (P<0.05) when L-dopa stimulation test was carried out for 60 and 90 minutes. Thus, it was first confirmed in this study that the ability to reserve hGH was very low for patients with endemic cretinism.

关 键 词：地方性 克汀病 椎体系流 智力 

分 类 号：R581.210.2[医药卫生—内分泌]