NB-UVB照射联合小剂量阿维A及外用他扎罗汀治疗重度斑块型银屑病疗效观察  

Effect of NB-UVB irradiation in combination with a small dose of acitretin and tazarotene 0. 05% gel on severe plaque psoriasis

作　　者：王伟[1] 蒋法兴[1] 牛丽敏[2] 李淑玲[2] 马超[2] 

机构地区：[1]安徽医科大学附属省立医院皮肤科,合肥230001 [2]安徽医科大学阜阳临床学院(阜阳市人民医院)皮肤科,阜阳236000

出　　处：《安徽医科大学学报》2013年第7期821-823,共3页Acta Universitatis Medicinalis Anhui

摘　　要：入选的重度斑块型银屑病患者146例,采用随机方式,将病例分为治疗组(A组,n=49),给予窄谱中波紫外线(NB-UVB)照射,每周3次,并每晚外用0.05%他扎罗汀凝胶1次;单纯NB-UVB治疗组(B组,n=48),单纯给予NB-UVB照射;单纯他扎罗汀治疗组(C组,n=49),单纯给予0.05%他扎罗汀凝胶外用。3组患者均给予小剂量阿维A口服,4、8周后分别评价疗效,疗程结束12周随访复发情况。结果显示,A、B、C 3组有效率分别为93.9%、72.9%、69.4%,3组间比较差异有统计学意义(P<0.05),未出现较严重的毒副作用,A组复发率也明显低于B组和C组。146 patients with severe plaque psoriasis were randomly divided into Group A, B and C. In Group A （Treatment Group）, 49 patients were given NB-UVB irradiation three times a week and applied tazarotene 0. 05% gel once a night. In Group B （ Control Group 1 ）, 48 cases were only given NB-UVB irradiation three times a week. The other patients in Group C （ Control Group 2） were only applied tazarotene 0.05 % gel every night. All the pa- tients were given a small dose [ 0. 3 - 0. 5 mg/（ kg ~ d） ] of acitretin. The clinical efficacy was evaluated 4 weeks and 8 weeks after treatment respectively. The follow-up recurrence was assessed 12 weeks after treatment. After 8 weeks＇ treatment, the effective rates of group A, B and C were 93.9%, 72. 9% and 69.4% respectively. The difference between Group A, Group B and Group A, Group C were both statistically significant （ P 〈 0. 05 ） and relative severe side-effects had not occurred. The recurrence rate in Group A was obviously lower than that of Group B and C.

关 键 词：斑块型银屑病 窄谱中波紫外线 他扎罗汀 阿维A 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]