HPLC-MS对“寒淫”致病及附子干预的代谢组学研究  

The Metabolomics Research on HPLC-MS in Cold Pathogen and Radix Aconiti Lateralis Preparata Intervention

作　　者：徐全壹[1] 欧阳利民[2] 王望华[3] 孙玉文[2] 谭从娥[4] 陈康[2] 王米渠[2] 

机构地区：[1]宁夏医科大学中医学院,宁夏银川750004 [2]成都中医药大学基础医学院,四川成都610072 [3]宁夏医科大学附属回医中医医院,宁夏吴忠751100 [4]陕西中医学院基础医学院,陕西咸阳712046

出　　处：《时珍国医国药》2013年第5期1254-1255,共2页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金项目(No.30873212);成都中医药大学校基金课题(No.ZRYY201110)

摘　　要：目的分析"寒淫"致病及附子干预的代谢组的代谢标志物。方法采用HPLC-MS结合模式识别技术对"寒淫"致病及附子干预的代谢组产物进行分析。结果对给药组和模型组的代谢组数据进行分析,发现55个差异代谢产物,涉及到18条生物学过程。结论 "寒淫"对动物机体影响显著,中药附子对"寒淫"有促使恢复机体平衡的作用。Objective To analyze metabolic marker on cold pathogen and radix aconiti lateralis preparata intervention. MethodsMetabolic markers on cold pathogen and radix aconiti lateralis preparata intervention were analyzed by HPLC-MS and pattern recognition. ResultsThese data on medicine group and model group were analyzed to find 55 difference metabolites and involve 18 biological processes. Conclusioncold pathogen influence significantly animals’ organism,and aconiti lateralis preparata can restore the organism balance.

关 键 词：寒淫 代谢组学 附子 标志物 

分 类 号：R2-03[医药卫生—中医学]