Novel chiral C_2-symmetric multidentate aminophosphine ligands for use in catalytic asymmetric reduction of ketones  

作　　者：Ya-Qing Xu Shen-Luan Yu Yan-Yun Li Zhen-Rong Dong Jing-Xing Gao 

机构地区：[1]State Key Laboratory of Physical Chemistry of Solid Surfaces,National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters and Department of Chemistry,College of Chemistry and Chemical Engineering,Xiamen University

出　　处：《Chinese Chemical Letters》2013年第6期527-530,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(No.21173176);Program for Changjiang Scholars and Innovative Research Team in University(No.IRTl 036);State Key Laboratory of Physical Chemistry of Solid Surfaces for financial support

摘　　要：A series of novel chiral C_2-symmetric multidentate aminophosphine ligands have been successfully synthesized by Schiff-base condensation of bis（o-formylphenyl）phenylphosphane and easily available monoprotected（1R,2R）-diaminocyclohexane.The catalytic properties of these ligands were investigated in Ir-catalyzed asymmetric transfer hydrogenation of various aromatic ketones,giving the corresponding optical active alcohols with up to 98%conversion and good ee under mild reaction conditions.A series of novel chiral C_2-symmetric multidentate aminophosphine ligands have been successfully synthesized by Schiff-base condensation of bis（o-formylphenyl）phenylphosphane and easily available monoprotected（1R,2R）-diaminocyclohexane.The catalytic properties of these ligands were investigated in Ir-catalyzed asymmetric transfer hydrogenation of various aromatic ketones,giving the corresponding optical active alcohols with up to 98%conversion and good ee under mild reaction conditions.

关 键 词：Asymmetric catalysis Iridium Aromatic ketones Aminophosphine ligands Asymmetric transfer hydrogenation 

分 类 号：O643.32[理学—物理化学]