补肾醒脑方对VD大鼠海马一氧化氮和一氧化氮合酶的影响  

Effect on NO and NOS in hippocampal of VD rats by Bushen Xingnao Prescription

作　　者：马英[1] 金秀东[1] 张绪东[1] 杨春壮[1] 

机构地区：[1]牡丹江医学院,黑龙江牡丹江157011

出　　处：《中医药信息》2013年第3期51-52,共2页Information on Traditional Chinese Medicine

基　　金：黑龙江省卫生厅医学科研课题(2006-401);牡丹江医学院科研课题(B200815)

摘　　要：目的:观察补肾醒脑方对血管性痴呆(VD)大鼠海马一氧化氮(NO)和一氧化氮合酶(NOS)含量的影响,探讨其治疗血管性痴呆的机制。方法:用双侧颈总动脉缺血再灌注制作VD大鼠模型,将大鼠随机分为正常组、模型组、西药组和中药组。采用大鼠跳台实验检测学习记忆能力;生化方法检测海马NO和NOS含量。结果:补肾醒脑方组大鼠跳台学习记忆所需次数比模型组减少(P<0.05);补肾醒脑方组海马NO和NOS含量比模型组降低(P<0.05)。结论:改善血管性痴呆大鼠海马NO和NOS含量是补肾醒脑方治疗血管性痴呆的机制之一。Objective：To observe the effect of NO and NOS in hippocampal of VD＇ s rats by Bushen Xingnao （BSXN） prescription. Method：The VD model rats were induced by ligating two sides of the total artery in neck, repeatedly used ischemia - reperfusion method to make the models. The models were randomly divided into normal group, model group ,western medicine group and Chinese medicine group. Observe VD rat models behavioral changes through using the diving platform experiment and the quantity of NO, NOS in hippocampal by using bio - chemical ways. Result ： In BSXN group the diving platform and the needed times of memory decreased （P 〈 0.05 ） compared with the model group ; the quantity of NO and NOS in hippocampal decreased （ P 〈 0.05 ） compared with the model group. Conclusion ： BSXN prescription can improve the contents of NO and NOS in hippocampal that may play a key role in the treatment of VD.

关 键 词：血管性痴呆 补肾醒脑方 学习记忆 NO NOS 

分 类 号：R285.5[医药卫生—中药学]