深裂锈毛莓氯仿部位的化学成分研究  

Chemical constituents in chloroform fraction from roots and rhizomes of Rubus reflexus var.lanceolobus

作　　者：黄艳[1,2] 梁冰[1,2] 刘元[1,2] 刘布鸣[1,2] 宋志钊[1,2] 韦韡[1,2] 林霄[1,2] 文志云[1,2] 

机构地区：[1]广西中医药研究院,广西南宁530022 [2]广西中药质量标准研究重点实验室,广西南宁530022

出　　处：《现代药物与临床》2013年第3期282-284,共3页Drugs & Clinic

基　　金：广西科技攻关项目(桂科攻11107010-3-4);广西青年基金资助项目(桂科基0991041)

摘　　要：目的研究深裂锈毛莓氯仿部位的化学成分。方法采用硅胶柱色谱和重结晶方法进行分离纯化,根据化合物的理化性质和波谱数据鉴定其结构。结果分离得到5个化合物,分别鉴定为2α,3β,19α-三羟基乌苏-12-烯-23-羧酸-28-O-β-D-吡喃葡萄糖酯(1)、2α,3β,19α-三羟基乌苏-12-烯-28-酸(2)、2α,3β,19α-三羟基乌苏-12-烯-23,28-二酸(3)、pseudosanguidiogenin A(4)、β-谷甾醇(5)。结论所有化合物均为首次从该植物中分离得到。Objective To study the chemical constituents in the chloroform fraction from the roots and rhizomes of Rubus reflexus var.lanceolobus.Methods The chemical constituents were separated and purified by silica gel column chromatography and recrytallization,and their structures were identified by physicochemical characteristics and spectral features.Results Five compounds were isolated and identified as 2α,3β,19α-trihydroxyurs-12-en-23-carboxyl-28-O-β-D-glucopyranosyl ester（1）,2α,3β,19α-trihydroxyurs-12-en-28-oic acid（2）,2α,3β,19α-trihydroxyurs-12-en-23,28-dioic acid（3）,pseudosanguidiogenin A（4）,and β-sitosterol（5）.Conclusion All the compounds are isolated from this plant for the first time.

关 键 词：深裂锈毛莓 2α 3β 19α-三羟基乌苏-12-烯-23-羧酸-28-O-β-D-吡喃葡萄糖酯 2α 3β 19α-三羟基乌苏-12-烯-28-酸 

分 类 号：R284.1[医药卫生—中药学]