利凡诺联合米非司酮用于中期引产的临床观察  

Clinical observation of Rivanol combined wih mifepristone on mid-term induction

作　　者：冯淑香[1] 杨丽丽[1] 王海霞[1] 

机构地区：[1]牡丹江医学院附属第二医院妇产科,黑龙江牡丹江157011

出　　处：《现代药物与临床》2013年第3期379-381,共3页Drugs & Clinic

摘　　要：目的观察利凡诺和米非司酮联合应用于中期妊娠引产中的临床疗效。方法选取2011年6月—2012年6月在牡丹江医学院附属第二医院行中期引产的产妇120例,随机分为对照组和观察组,每组60例。其中对照组直接经羊膜腔注射100mg利凡诺,观察组在注射利凡诺的基础上,口服米非司酮,首次剂量50mg,以后每12h口服一次,25mg/次,总剂量为150mg。结果观察组的宫缩时间、胎盘排出时间、总产程、出血量及疼痛评分明显均低于对照组(P<0.05);观察组引产过程中并发症的发生率为6.67%,对照组为30.00%,两组比较差异有统计学意义(P<0.05)。结论利凡诺联合米非司酮应用于中期妊娠引产过程中疗效较好,不仅缩短了引产产程,且患者的疼痛较轻,并发症较少,值得在临床上推广应用。Objective To observe the effect of Rivanol combined with mifepristone on mid-term induction.Methods Patients（120 cases） who accepted mid-term induction in Second Affiliated Hospital of Mudanjiang Medical College from June 2011 to June 2012 were randomly divided into control group and observation group,and 60 cases in each group.The patients in the control group were iv administered with 100 mg Rivanol from amniotic cavity directly.The patients in the observation group were po administered with mifepristone,and the first dosage was 50 mg.Then the patients took orally 25 mg every 12 h,and the total dosage was 150 mg.Results The time of uterine contraction,placenta expulsion maternal,and total production process in the observation group were shorter than that in the control group（P ＆lt; 0.05）.At the same time,the amount of bleeding and pain scores were significantly lower than those in the control group（P ＆lt; 0.05）.The incidences of the complications in the observation and control groups were 6.67% and 30.00% with significant difference（P ＆lt; 0.05）.Conclusion Rivanol combined with mifepristone on the mid-term induction has a better effect with fewer complications.It could not only shorten the production process of induction,but also reduce pain of patients,which is worth the clinical promotion.

关 键 词：利凡诺 米非司酮 中期引产 临床疗效 

分 类 号：R969.4[医药卫生—药理学]