克霉唑栓与乳酸杆菌活菌胶囊联合治疗复杂性外阴阴道假丝酵母病的临床疗效分析  

Clinical effects of combination of clotrimazole suppositories and living preparation of lactobacillus on vulvovaginal candidiasis

作　　者：李桢理[1] 叶宇齐[1] 伏荣红[2] 

机构地区：[1]江苏省中西医结合医院妇产科,南京21002 [2]南京中医药大学

出　　处：《中国实用医药》2013年第14期22-23,共2页China Practical Medicine

摘　　要：本文旨在探讨克霉唑栓与乳酸杆菌活菌胶囊联合治疗复杂性外阴阴道假丝酵母病(VVC)的临床疗效。将84例就诊于江苏省中西医结合医院妇产科的复杂性VVC患者随机平均分为两组:治疗组给予阴道内放置克霉唑栓与乳酸杆菌活菌胶囊联合治疗;对照组单用阴道内放置克霉唑栓。结果显示,治疗组复杂性VVC 42例(失访2例),29例治愈,8例显效,总有效率为88.10%;对照组复杂性VVC42例(失访3例),20例治愈,9例显效,总有效率为69.05%。两组总有效率差异有统计学意义(P<0.05)。两组治愈及显效者均在治疗停药后12周复查。治疗组失访2例,复发3例,复发率为7.65%;对照组失访3例,复发9例,复发率为23.08%。结果提示,克霉唑栓与乳酸杆菌活菌胶囊联合治疗复杂性VVC安全、有效,可在临床推广。The present paper aims to investigate the clinical effects of combination of clotrimazole suppositories and living preparation of lactobacillus on vulvovaginal candidiasis.A total of 84 patients with vulvovaginal candidiasis from the Department of Obstetrics and Gynecology,Jangsu Province Hospital on Integration of Chinese and Western Medicine were selected and divided into the control group and experimental group.There were 42 cases in each group.The patients in the control group were only given clotrimazole suppositories,while the patients in the experimental group were given clotrimazole suppositories and living preparation of lactobacillus.In the experimental group,2 cases were lost to follow-up,29 markedly effective,8 effective.The total effective rate was 88.10%.In the control group,3 cases were lost to follow-up,20 markedly effective,9 effective.The total effective rate was 69.05%.The effective rate in the experimental group was significantly higher than that in the control group（P＆lt;0.05）.The recurrence rate in the experimental group was 7.65%,significantly lower than 23.08% in the control group（P＆lt;0.05）.The results suggest that combination of clotrimazole suppositories and living preparation of lactobacillus is safe and effective in treatment of vulvovaginal candidiasis.

关 键 词：外阴阴道假丝酵母病 克霉唑栓 乳酸杆菌活菌胶囊 

分 类 号：R711.3[医药卫生—妇产科学]