甲状腺功能亢进症与性腺功能的关系探讨  

The functional change of gonad in patients with hyperthyroidism

作　　者：王琼[1] 王莉[2] 付 建芳 石敏[1] 翟文松[1] 姬秋和[1] 李晓苗[1] 

机构地区：[1]第四军医大学西京医院内分泌代谢科,西安710032 [2]陕西省宝鸡市中心医院肾病糖尿病科

出　　处：《陕西医学杂志》2013年第6期721-723,共3页Shaanxi Medical Journal

摘　　要：目的:探讨甲状腺功能亢进症(甲亢)患者病情的严重程度及病程长短与性腺功能之间的关系。方法:对63例甲亢患者进行实验室检查,按病程长短及甲亢严重程度分组,分别测定血清中甲状腺激素、甲状腺自身抗体、促卵泡成熟激素(FSH)、促黄体生成激素(LH)、雌二醇(E2)、孕酮(P)、睾酮(T)和垂体泌乳素(PRL),判断甲状腺功能与性腺功能状态。结果:除男性甲亢患者P外,重度甲亢组与中度、轻度甲亢组比较,FSH、LH、E2、T、PRL均有显著性差异(P<0.05),而病程较长组与病程较短组比较,FSH、LH、E2、T、PRL亦有显著性差异(P<0.05)。结论:甲亢程度越重,病程越长,对性腺功能的抑制程度越大。Objective： To explore the illness severity and duration in patients with hyperthyroidism and relationships between gonad function, providing rationale for clinical treatment. Methods： Serum thyroxin, thyroid autoantibody, follicle-stimulating hormone（ FSH）, leuteinizing hormone（LH）, estradoil （ E2 ）, progesterone（P）, testosterone（T）, prolactin（PRL） was detected and Grouped by course length and severity of hyperthyroidism. Results： Addition to the progesterone in male patients with hyperthyroidism, Severe hyperthyroidism group and moderate, mild hyperthyroidism comparison, FSH,LH,E2 ,T,PRL has significant differences（P〈0.05）, and comparison of course longer and shorter course groups, FSH, LH, E2 ,T,PRL also showed a marked difference（P〈0.05）. Conclusion： Hyperthyroidism more heavy, long course, the greater the degree of inhibition of gonadal function.

关 键 词：甲状腺功能亢进症 性腺功能减退症 因果律 

分 类 号：R581.1[医药卫生—内分泌]