cis-Nitenpyram Analogues Bearing Acyloxy Segments Anchored on the Tetrahydropyrimidine Ring： Synthesis, Insecticidal Activities and Molecular Docking Studies  

作　　者：SUN Chuan-wen WU Ying CHEN Yan-xia NAN Shi-bin ZHANG Wang-geng 

机构地区：[1]College of Life and Environment Sciences, Shanghai Normal University, Shanghai 200234, P. R. China [2]Jiangsu Institute of Eeomones Co., Ltd., Jintan 213200, P. R. China

出　　处：《Chemical Research in Chinese Universities》2013年第3期477-482,共6页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China（Nos.21042010, 21102092 and 30870560）, the Key Scientific ＂Twelfth Five-Year＂ National Technology Support Program, China（No.2011BAE06B01-17）, the Innovation Project of Shanghai Education Commission, China（No. 12YZ078）, the Program of the Food Safety and Nutrition Innovation Team of Shanghai Normal University, China（No.DXL123） and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, China（No.07dz22303）.

摘　　要：A series of novel cis-nitenpyram analogues bearing acyloxy segments anchored on the tetrahydropyrimi-dine ring was designed and synthesized. Preliminary bioassays indicate that all the nitenpyram analogues 3a--3n exhibit good insecticidal activities against Nilaparvata lugens and Aphis medicaginis at 100 mg/L, while analogue 3k affords the best activity in vitro and the lethal concentration 50（LC50） values（0.187, 0.214 mg/L） are close to that of nitenpyram. The structure activity relationships（SARs） suggest that their insecticidal potency is influenced by the species of acyloxy segments. The docking results reveal that analogue 3k forms stronger hydrogen-bonding with the nAChR, which explain the structure activity relationships（SARs） observed in vitro and imply that the strategies of our designed nitenpyram analogues are feasible.A series of novel cis-nitenpyram analogues bearing acyloxy segments anchored on the tetrahydropyrimi-dine ring was designed and synthesized. Preliminary bioassays indicate that all the nitenpyram analogues 3a--3n exhibit good insecticidal activities against Nilaparvata lugens and Aphis medicaginis at 100 mg/L, while analogue 3k affords the best activity in vitro and the lethal concentration 50（LC50） values（0.187, 0.214 mg/L） are close to that of nitenpyram. The structure activity relationships（SARs） suggest that their insecticidal potency is influenced by the species of acyloxy segments. The docking results reveal that analogue 3k forms stronger hydrogen-bonding with the nAChR, which explain the structure activity relationships（SARs） observed in vitro and imply that the strategies of our designed nitenpyram analogues are feasible.

关 键 词：cis-Nitenpyram analogue Acyloxy segment Hydrogen-bonding action Insecticidal activity Molecular docking 

分 类 号：TQ453.299[化学工程—农药化工] S482.39[农业科学—农药学]