甘油脱氢酶生产工艺仿真设计与技术经济分析  

Process simulation design and techno-economic analysis of production technology of glycerol dehydrogenase

作　　者：曾宏[1,2] 方柏山[3,4] 汪排芬[2] 张婷婷[1] 

机构地区：[1]华侨大学化工学院,福建厦门361021 [2]泉州师范学院化学与生命科学学院,福建泉州362000 [3]厦门大学化学化工学院,福建厦门361005 [4]厦门大学醇醚酯化工清洁生产国家工程实验室,福建厦门361005

出　　处：《化工学报》2013年第6期2169-2176,共8页CIESC Journal

基　　金：福建省高校产学合作科技重大项目(2010H6023);福建省教育厅A类科技项目(JA11219);泉州市技术研究与开发基金项目(2010G6)

摘　　要：甘油脱氢酶（glycerol dehydrogenase，GDH）是以甘油为底物生产二羟基丙酮（dihydroxyacetone，DHA）和1，3-丙二醇（1，3-propanediol，PDO）的关键酶之一。以甘油为底物的微生物典型代谢途径如图1所示，甘油经甘油脱水酶（glycerol dehydratase，GDHt）催化生成3-羟基丙醛（3-hydroxypropionaldehyde，3-HPA），Glycerol dehydrogenase （GDH） is one of the key enzymes for production of dihydroxyacetone （DHA） and 1,3-propanediol （PDO） by the enzymatic method. Based on scale-up of laboratory experiment, the Superpro Designer emluator was used to design and simulate the whole process of industrial technology for GDH production, by coupling with costing and economic evaluation of flowsheeting. Simulation results indicated that the process design was reasonable with main process data in agreement with experimental results. The economic analysis showed that raw materials and supplies shared the larger proportion of operating cost reaching 16% and 60% respectively. The expected return on investment （ROD was to reach 50.48% of approximately 75.36 million CNY project total investments of a 17.9 t. a -1 plant, as the after-tax profits about 21.08 million CNY . a -1.

关 键 词：甘油脱氢酶 生产工艺 过程模拟 经济分析 

分 类 号：TQ018[化学工程] TH162[机械工程—机械制造及自动化]