降香化学成分、药理作用及药代特征的研究进展  

Advance in studies on chemical constitutions,pharmacological mechanism and pharmacokinetic profile of Dalbergiae Odoriferae Lignum

作　　者：杨志宏[1] 梅超[1] 何雪辉[1,2] 孙晓波[1] 

机构地区：[1]中国医学科学院北京协和医学院药用植物研究所,北京100193 [2]河北北方学院,河北张家口075000

出　　处：《中国中药杂志》2013年第11期1679-1683,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81102879;81273654);国家"重大新药创制"科技重大专项(2012ZX09501001;2013ZX09103002-022);高等学校博士学科点专项科研基金项目(20101106120049);国家科技支撑计划项目(2008BAI51BO2)

摘　　要：降香是一味常用的活血化瘀中药,具有行气活血、止痛、止血的功效,其主要化学成分为挥发油类和黄酮类化合物。现代药理研究表明,降香具有舒张血管、增加冠脉流量、抗氧化、抗炎、抗肿瘤等作用。降香作为一种具有深入开发潜力的特色中药,常与其他中药配伍用于心脑血管类疾病的治疗。该文将对近几年来国内外有关降香的化学成分、药理作用、体内代谢过程及配伍应用方面的研究报道进行较为系统的梳理和综述,旨在为降香的深入研究工作提供参考。Dalbergiae Odoriferae Lignum is a traditional Chinese medicine （TCM） commonly used for promoting blood circulation, relieving pain and removing blood stasis. Volatile oil and flavonoid compounds are two main chemical constituents of Dalbergiae Odoriferae Lignum. Modern pharmacological studies show that Dalbergiae Odoriferae Lignum has many effects, such as relaxing blood, increasing blood flow of coronary, anti-oxidation, anti-inflammation and antitumor. Dalbergiae Odoriferae Lignum, as a characteristic TCM with the potential of further development, is generally compatible with other TCMs to treat cardio-cerebral vascular diseases. This article summarizes studies on chemical composition, pharmacological action, pharmacokinetic procfile in vivo and TCM compatibility in recent years, in order to provide references for further studies.

关 键 词：降香 化学成分 药理作用 体内过程 配伍应用 研究进展 

分 类 号：R282.7[医药卫生—中药学]