正交设计法优选银杏黄酮凝胶骨架片处方工艺  

Formulation optimization of ginkgo flavonoids matrix tablets by orthogonal design

作　　者：郭迎新[1] 李非[1] 赵倩倩[1] 徐璐[1] 潘卫三[1] 萧伟[2,3] 杨星钢[1,3] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016 [2]江苏康缘药业股份有限公司,江苏连云港222001 [3]中药制药过程新技术国家重点实验室,江苏连云港222001

出　　处：《中国中药杂志》2013年第11期1725-1730,共6页China Journal of Chinese Materia Medica

基　　金：国家重点基础研究发展计划(973)项目(2012CB724001);中药制药过程新技术国家重点实验室开放基金项目(SKL2010Z0301)

摘　　要：缓释片制剂以其特有的优点,已成为当前缓控释研究领域的热点之一。针对普通银杏制剂在治疗心脑血管疾病中存在的缺点,该文研制了银杏黄酮凝胶骨架片,并对制备该制剂所采用的骨架材料、黏合剂、填充剂的种类及用量进行了考察与评价,同时采用正交设计试验,优选出最佳处方。采用零级、一级、Higuchi及Ritger-pappas模型对药物总黄酮醇苷释放曲线进行拟合,进而探讨药物释药机制。Sustained-release tablet has become one of the hottest research spots in the area of sustained release preparations with its unique advantages. At present, a series of shortcomings were exited in the ordinary ginkgo preparations, which were used for the treatment of cardiovascular and cerebrovascular diseases. In order to avoid these shortcomings, ginkgo flavonoids matrix tablets were prepared in this paper. Furthermore, the amount and varieties of matrix material, adhesives and fillers were investigated. Meanwhile, the formulation was optimized by using the method of orthogonal design, and Zero-order, First-order, Higuchi, Ritger-peppas equation were used for the model fitting and mechanism discussing of drug release.

关 键 词：银杏黄酮 骨架片 正交设计 总黄酮醇苷 释药机制 

分 类 号：R283[医药卫生—中药学]