补骨脂定抗实验性绝经后骨质疏松的效应及作用机制研究  

Study on effect of psoralidin on anti-experimental postmenopausal osteoporosis and its mechanism

作　　者：李劲平[1] 王小静[1] 曾英[2] 林清[1] 莫新民[2] 刘仕杰[2] 杨军[2] 

机构地区：[1]中南大学药学院,湖南长沙410013 [2]湖南中医药大学,湖南长沙410007

出　　处：《中国中药杂志》2013年第11期1816-1819,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金面上项目(30873291;81273816)

摘　　要：目的:观察补骨脂定抗去势雌鼠骨质疏松的疗效,并初步探讨其作用机制。方法:取4月龄清洁级SD雌性大鼠60只,分为5组,分别为假手术组、模型组、补骨脂定低、高剂量组(4,16 mg.kg-1)及阳性对照壮骨止痛胶囊组,每组12只。13周后取血和骨标本检测骨密度,骨生物力学,病理形态学,血清E2,CT等指标。结果:补骨脂定能明显增加去势大鼠腰椎和股骨骨密度(P<0.05)和骨小梁面积率(P<0.05),增强股骨最大抗弯强度(P<0.05),显著升高血清E2和CT水平(P<0.05)。结论:补骨脂定对绝经后骨质疏松症具有良好疗效,其作用机制可能部分通过E2,CT等途径发挥作用。Objective： To observe the effect of psoralidine in rats with ovariectomy, and preliminarily study its mechanism. Method： Sixty female Sprague-Dawley rats were divided into 5 groups： the sham operation group, the model group, the psoralidine low-dose group （4 mg·kg-1）, the psoralidine high-dose group （16 mg·kg-1） and the Zhuangguzhitong capsule group, with 12 rats in each group. Thirteen weeks later, their blood and bone samples were collected to detect bone density, bone biochemistry, pathomorphology, serum E2 and CT. Result： Psoralidine could up-regulate the bone density of lumbar vertebra and thighbone of rats with ovariectomy（P〈0.05）, the maximum bending strength of thighbone（P〈0.05）, and serum E2 and CT（P〈0.05）. Conclusion： Psoralidine has a good active effect on postmenopausal antiosteoporosis. Its mechanism may be related to such pathways as E2 and CT.

关 键 词：骨质疏松症 补骨脂定 

分 类 号：R285.5[医药卫生—中药学]