实时三平面斑点追踪成像技术评价糖尿病患者左室整体收缩功能  

Evaluating the Left Ventricular Global Systolic Function of Patients with Diabetes Mellitus by the Real-time Three-plane Speckle Tracking Imaging

作　　者：张晓玲[1] 魏薪[1] 孔令秋[1] 刘敏[1] 唐红[1] 

机构地区：[1]四川大学华西医院心内科,成都610041

出　　处：《生物医学工程学杂志》2013年第3期513-517,共5页Journal of Biomedical Engineering

摘　　要：应用超声实时三平面斑点追踪成像技术(RT-3PSTI)评价糖尿病(DM)患者左室长轴方向整体收缩功能。病例组为临床确诊为2型DM且左室射血分数(LVEF)正常的患者,根据糖化血红蛋白(HbA1c)控制水平,分为DM1(HbA1c<7%,31例)和DM2(HbA1c≥7%,37例)两组,对照组63例。采用RT-3PSTI,应用自动功能成像软件分析心尖三切面纵向收缩期峰值应变(GLPS),包括心尖四腔心GLPS(GLPS-A4C)、心尖两腔心GLPS(GLPS-A2C)、心尖左室长轴GLPS(GLPS-LAX)及平均GLPS(GLPS-Avg)。结果显示临床基线资料在三组间无统计学差异(P>0.05);DM1、DM2组的室壁厚度及心肌质量指数与对照组相比均有统计学差异(P<0.05);左室内径、容积及LVEF在三组之间无统计学差异(P>0.05);DM2组的GLPS-LAX、GLPS-A2C、GLPS-Avg与DM1组及对照组相比均有统计学差异(P<0.05),GLPS-A4C与对照组相比有统计学差异(P<0.05);DM1组的各应变测值与对照组相比差异均无统计学意义(P>0.05)。RT-3PSTI可准确评价长轴方向左室整体收缩功能,并可早期发现血糖控制不佳的DM患者亚临床的左室收缩功能减低。Our study was aimed to evaluate the left ventricular （LV） global longitudinal systolic function of patients with diabetes mellitus （DM） using real-time three-plane speckle tracking imaging （RT-3P STI）. The case group was the patients of type 2 DM with normal LV ejection fraction （EF）. Then according to glycated hemoglobin （HbAlc） control level, the case group was divided into two groups, including DM1 （HbA1c〈7%, n= 31） and DM2 （HbAlc ≥7%, n=37） ; 63 matched volunteers were chosen as control group. Conventional measurements of the LV size and function were performed. We then applied the automatic function imaging to analyze the global longitudinal systolic peak strain （GLPS） of the three apical views online, including the GLPS of apical four chamber view （GLPS-A4C）, the GLPS of apical two chamber view （ GLPS-A2C）, the GLPS of apical long axis view （GLPS-LAX）, and then generating the average GLPS （GLPS-Avg）. The experimental results showed that there was no statistical difference in clinical baseline characteristics among the three groups （P〉0.05） . However, there were statistical differences in the ventricular wall thickness and the LV mass index of the DM1 and DM2 groups compared with that of the control （P〈0.05）. No significant differences were found in LV diameters, volumes, LVEF among the three studied groups （P〉0.05）. We also found significant differences in GLPS-LAX, GLPS-A2C, GLPS-Avg when we compared DM2 group with those of the DM1 group or the control （P〈0.05）. We found a statistical difference in GLPS-A4C only when we compared the DM2 group with the control（P〈0.05）, and no statistical difference in the strains of the three views between DM1 group and control （P〉0. 05）. RT-3P STI could not only accurately be used to evaluate the LV global longitudinal systolic function, but could also reflect the reduction of sub-clilical systolic function in DM patients with poor blood glucose control in the early stage.

关 键 词：糖尿病 实时三平面 斑点追踪成像技术 收缩功能 

分 类 号：R587.1[医药卫生—内分泌]