新生儿期先天梅毒75例及其生母血清学检测结果分析  

Serology Results of 75 Cases of Neonatal Congenital Syphilis of Children and Natural Mother

作　　者：鲁东平[1] 付敏 鲁菊香 李琛 张荣[1] 梁冬梅[1] 李湘辉[1] 

机构地区：[1]深圳市宝安区慢性病防治院皮肤科,广东深圳518133 [2]深圳市宝安区沙井人民医院皮肤科,广东深圳518104 [3]广州市越秀区儿童医院,广东广州510115 [4]深圳市石岩人民医院儿科,广东深圳518108

出　　处：《中国皮肤性病学杂志》2013年第6期591-592,604,共3页The Chinese Journal of Dermatovenereology

基　　金：2011年宝安区第二批科技计划项目(20110567)

摘　　要：目的了解新生儿期先天梅毒(neonatal congenital syphilis,NCS)患儿及生母血清学检查结果的特点,为科学诊断NCS提供依据。方法对深圳市宝安区部分医疗机构近7年诊断的NCS患儿及生母梅毒血清学检查结果进行回顾性分析。结果有75例患儿临床诊断为NCS,53例患儿血清TRUST滴度≥1∶16,占70.67%,TPPA,19SIgM-TPPA均阳性;NCS的TRUST滴度≥孕母滴度4倍者27例(36.00%),且这些患儿的TRUST滴度均≥1∶16。结论 19SIgM-TPPA联合TRUST和TPPA检测可提高NCS尤其是新生儿期先天潜伏梅毒(neonatal congenital latent syphilis,NCLS)诊断的准确性;新生儿血清TRUST滴度≥1∶16和/或生母在分娩时TRUST滴度≥1∶16,对早期诊断NCS有参考价值。Objective To analyze the serological test results characteristics of neonatal congenital syphilis （NCS） children and their natural mother, and provide the scientific reference for diagnosis of NCS. Methods Data of serological test results of NCS children and mother＇s were from part of the medical institutions in Bao＇an District in the past seven years, serological results were retrospectively analyzed. Results Seventy-five cases of newborns were clinically diagnosed as NCS,53 cases were serum TRUST titer ≥ 1： 16（accounting for 70. 67% ）, TPPA and 19S-IgM-TPPA were positive. There were 27 （36.00%） cases of NCS TRUST titer /〉 4 times of maternal titer, and these newborns TRUST titer ≥ 1： 16. Conclusion 19S-IgM-TPPA joint TRUST and TPPA testing can improve the NCS, especially neonatal congenital latent syphilis （NCLS） diagnostic accuracy; neonatal TRUST serum titer ≥ 1： 16,and （or） maternal serological TRUST titer≥ 1： 16 at birth is a value reference to the early diagnosis of NCS.

关 键 词：先天梅毒 新生儿期 生母 血清学结果 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]