耳背静脉放血对扁平疣疣体组织病理学的影响  

Analysis in Histopathological Changes in Lesional Skin of Plane Warts Treated with Posterior Auricular Vein Bloodletting Therapy

作　　者：颜廷凯[1] 曹碧兰[1] 孙文倩[1] 袁伟[1] 曾令芬[1] 陶锐[1] 曾霓[1] 黄洋[1] 熊琦[1] 

机构地区：[1]贵州省遵义医学院皮肤科,贵州遵义563000

出　　处：《中国皮肤性病学杂志》2013年第6期621-622,628,共3页The Chinese Journal of Dermatovenereology

基　　金：贵州省中医药管理局资助项目(D-335)

摘　　要：目的动态观察耳背静脉放血疗法治疗扁平疣后疣体的组织病理学特征。方法采集耳背静脉放血疗法治疗扁平疣患者治疗前、后疣体组织标本并进行常规HE染色,观察其组织病理变化情况。结果反应1周内,基底层及真皮浅层血管周围见大量淋巴细胞浸润;反应2周内,浸润的淋巴细胞向上推移,累及棘细胞层的中层,棘细胞水肿;反应超过2周,淋巴细胞浸润几乎累及疣体全层,角质形成细胞破裂、溶解和坏死。结论耳背静脉放血治疗扁平疣的机制可能是通过诱导淋巴细胞向表皮内浸润,产生免疫应答,导致疣体脱落。Objective To explore the histopathological changes dynamically of warts after the posterior auricular vein bloodletting therapy. Methods Routine hematoxylin-eosin （HE） staining was used to detect the histopatho- logical changes in plana warts at different stages after the posterior auricular vein bloodletting therapy. The pathological manifestations were observed under light microscope. Results Lymphocytics infiltration was found around dermis shallow layer of blood vessels and stratum basale in the reaction within one week. Less than two weeks, lymphocytes grew up to the interim stratum spinosum causing prickle ceils edema. For more than two weeks, all strata of epidermis were involved by lymphocytics infiltration, leading to cytolysis and cy- toclasis of keratinocyte. Conclusion The mechanism of the posterior auricular vein bloodletting therapy may be explained by inducing lymphoid cells into epidermal infiltration, immune responses being activated and then the plana warts were rejected.

关 键 词：扁平疣 耳背静脉放血 病理学 

分 类 号：R752.52[医药卫生—皮肤病学与性病学]