丝裂霉素C在治疗气道瘢痕狭窄中的应用  

The application of mitomycin C in treatment of airway scarring stenosis

作　　者：谢斌[1] 殷敏[1] 朱歆洁[1] 林子萍[1] 

机构地区：[1]南京医科大学第一附属医院江苏省人民医院耳鼻咽喉科,南京210029

出　　处：《临床耳鼻咽喉头颈外科杂志》2013年第12期654-656,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：江苏高校优势学科建设工程(No:PAPD2010-2013);江苏省"科教兴卫工程"医学重点学科(No:XK200719)

摘　　要：目的:探讨丝裂霉素C在治疗气道狭窄中的可行性和疗效。方法:回顾性分析2008-2012年丝裂霉素C治疗11例气道狭窄患者的临床资料,其中鼻咽、后鼻孔闭锁2例,喉咽狭窄1例,喉气管狭窄8例。所有患者均在全身麻醉腔镜下手术,术中切除狭窄处的瘢痕组织,创面用0.4mg/ml丝裂霉素C棉片局敷,每次5min,反复5次。结果:所有患者术后2个月随访无再次狭窄,2例鼻咽、后鼻孔闭锁者通气满意,8例喉气管狭窄者均顺利拔管,1例喉咽狭窄者能接近正常吞咽。结论:腔镜下使用丝裂霉素C治疗气道狭窄是一种安全有效的治疗方法,对1～2期喉气管狭窄成功率高,应作为首选的治疗方法。Objective：To explore the feasibility and efficacy of mitomycin C（MMC） in the treatment of airway scarring stenosis.Method：The clinical materials of 11 patients with airway stenosis treated with MMC from 2008 to 2012 were analyzed retrospectively,including atresiaofnasopharynx /choanal atresia（2 cases）,pharyngostenosis（1 case）,and laryngotracheal stenosis（8 cases）.All were treated with endoscopic surgery under general anesthesia.Patients received topical application of MMC（0.4mg/ml） to the lesion for 5 minutes after the scar tissue removed and repeated five times.Result：No patients occurred restenosis in 2 months＇ follow-up postoperative.Two patients with atresiaofnasopharynx /choanal atresia achieved satisfactory ventilation outcome,8 patients with laryngotracheal stenosis decannulated successfully,1 patients with pharyngostenosis achieved near normal deglutition.Conclusion：MMC in endoscopic airway surgery is safe and effective in the treatment of airway stenosis and offers a high success rate for patients with grade 1-2 stenosis.It should be used as a first method in the treatment of airway stenosis.

关 键 词：内镜检查 喉狭窄 气管狭窄 丝裂霉素C 

分 类 号：R768.1[医药卫生—耳鼻咽喉科]