心脏型脂肪酸结合蛋白预测老年不稳定型心绞痛患者预后的价值  

Value of heart-type fatty acid binding protein to predicting senile unstable angina pectoris

作　　者：钱海燕[1] 黄觊[2] 杨跃进[1] 杨艳敏[3] 张朝阳[3] 

机构地区：[1]中国医学科学院 北京协和医学院 国家心血管病中心 阜外心血管病医院冠心病诊治中心 心血管疾病国家重点实验室,北京市100037 [2]首都医科大学附属北京安贞医院心内科,北京市100029 [3]中国医学科学院 北京协和医学院 国家心血管病中心 阜外心血管病医院急诊科 心血管疾病国家重点实验室,北京市100037

出　　处：《中华实用诊断与治疗杂志》2013年第6期533-535,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：国家自然科学基金(81000091);国家自然科学基金(81000130);北京新星计划(2008B78;北京市科学技术委员会)

摘　　要：目的探讨心脏型脂肪酸结合蛋白(heart-type fatty acid binding protein,H-FABP)预测老年不稳定型心绞痛患者预后的价值。方法年龄≥60岁不稳定型心绞痛患者175例,分为H-FABP阳性组48例和阴性组127例,记录并分析2组资料及12个月随访结果。结果阳性组年龄、体质量指数大于阴性组(P<0.05),吸烟、冠心病家族史、既往心肌梗死病史、冠状动脉介入和旁路移植手术史及合并糖尿病比例明显高于阴性组(P<0.05),左室射血分数低于阴性组(P<0.05);冠状动脉造影显示,阳性组多支、弥漫甚至闭塞病变、累及左主干和前降支比例高于阴性组(P<0.05);随访12个月,阳性组心脏事件发生率明显高于阴性组(P<0.01)。结论 H-FABP可用于≥60岁不稳定型心绞痛患者的危险分层和1a预后的预测。Objective To explore the value of heart-fatty acid binding protein （H-FABP） to predicting the prognosis of senile unstable angina pectoris （UAP）. Methods A total of 175 UAP patients aged 60 years or older were divided into positive H-FABP group and negative H-FABP group, and were recorded and analyzed the clinical data and 12-month follow-up survey results. Results The age was older, body mass index was larger, and the proportions of smoking history, family history of coronary heart disease, previous myocardial infarction and coronary artery bypass history, and diabetes mellitus were higher in positive group than those in negative group （P〈0.05）. The left ventricular ejection fraction was lower in positive group than that in negative group （P〈0.05）. Coronary angiography results showed that the rates of multi-vesse lesions, diffusive and occlusive lesions, and left main and left anterior descending lesions were higher in positive group than those in negative group （P〈0.05）. After the follow-up survey for 12 months, the incidence of major adverse cardiovascular events was significantly higher in positive group than that in negative group （P〈0.01）. Conclusion H-FABP is valuable to identify the high-risk population and to predict the prognosis of UAP patients aged 60 years or older.

关 键 词：不稳定型心绞痛 老年 心脏型脂肪酸结合蛋白 预后 

分 类 号：R541.4[医药卫生—心血管疾病]