氯冉酸荷移分光光度法测定尿样中盐酸非索非那定  

Spectrophotometric Determination of Fexofenadine Hydrochloride in Urine Based on Charge Transfer Reaction with Chloranilic Acid

作　　者：孙雪花[1] 柴红梅[1] 高楼军[1] 李永利[1] 

机构地区：[1]延安大学化学与化工学院,陕西延安716000

出　　处：《分析科学学报》2013年第3期413-415,共3页Journal of Analytical Science

基　　金：陕西省重点实验室项目(No.12JS119);延安大学自然科学专项基金重点项目(No.YDZD2011-06)

摘　　要：建立了氯冉酸荷移分光光度法测定盐酸非索非那定含量的新方法。结果表明:盐酸非索非那定和氯冉酸在正丙醇介质中形成稳定的1∶1型荷移络合物,并在529nm波长处有最大吸收,表观摩尔吸光系数为3.3×103 L·mol-1·cm-1,盐酸非索非那定质量浓度在0.2～100mg·L-1范围内符合比耳定律,相关系数R=0.9974,检出限为0.12mg·L-1。该法用于尿样及药片中盐酸非索非那定含量的测定,其回收率为99.87%～101.2%。A spectrophotometric method was developed for the determination of fexofenadine hydrochloride in tablets through charge-transfer between fexofenadine hydrochloride and chloranilic acid.The results showed that fexofenadine hydrochloride reacted with chloranilic acid to form a stable 1∶1charge-transfer complex in n-propyl alcohol.The apparent molar absorption coefficient of the complex was 3.3×103L.mol-1.cm-1 at 529nm.The linear range of Fexofenadine hydrochloride was 0.2-100 mg.L-1.The detection limit was 0.12 mg.L-1.The method is simple,rapid and reliable for determination of fexofenadine hydrochloride in urine and tablets with recoveries of 99.87%-101.2%.

关 键 词：分光光度法 荷移反应 盐酸非索非那定 氯冉酸 

分 类 号：O657.32[理学—分析化学]