注射用复合辅酶在非体外循环冠状动脉旁路移植术中的心肌保护作用  

Effect of coenzyme complex on myocardial protection in patients under off-pump coronary artery bypasses graft

作　　者：穆东亮[1] 李文荣[2] 王东信[1] 李纯青[1] 

机构地区：[1]北京大学第一医院麻醉科,北京100034 [2]北京大学第一医院中心手术室,北京100034

出　　处：《中国新药杂志》2013年第11期1303-1306,共4页Chinese Journal of New Drugs

摘　　要：目的:探索临床推荐剂量的注射用复合辅酶在非体外循环冠状动脉旁路移植术中的心肌保护作用。方法:采用随机双盲对照研究,入选择期非体外循环下冠状动脉旁路移植术患者60例并分为2组,均在麻醉诱导前30 min接受试验药物:治疗组为复合辅酶A 400 U/辅酶I 0.2 mg;对照组患者接受5%葡萄糖作为安慰剂。分别在术前1 d、术后即刻和术后4,8,12 h采集血样测定心肌肌钙蛋白和心肌酶谱,同时记录围术期其他相关变量。结果:两组患者的围术期资料无统计学差异。两组患者术后心肌肌钙蛋白和心肌酶谱均增高,试验组心肌肌钙蛋白在术后8 h略低于对照组,但无统计学差异;各时间点的心肌酶谱指标两组间比较均无统计学差异。结论:临床推荐剂量的复合辅酶在非体外循环冠状动脉旁路移植术中的心肌保护作用仍有待于进一步研究。Objective： To investigate the effect of coenzyme complex at clinical recommended dosage on myocardial protection in patients under off-pump coronary artery bypass graft. Methods： In a double blind randomized control trial, 60 patients who underwent selective off-pump coronary artery bypass graft were enrolled and randomly divided into two groups. They were treated with coenzyme complex （A 400 U, I 0.2 mg） 30 min before induction of anesthesia, or with 5% glucose as placebo （control）. Blood samples were obtained at fixed time points： one day before operation, and postoperative 0, 4, 8 and 12 h. Cardiac troponin I （cTnI） and myocardial enzymes were tested. We also recorded perioperative related data. Results： There was no significant difference between two groups in perioperative data. cTnI was lower after postoperative 8 h in coenzyme complex group than in control group, but without statistical difference. Myocardial enzyme also showed no significant changes at each time point between two groups. Conclusion： The effect of complex coenzyme at clinically recommended dose on myocardial protection during off-pump coronary artery bypass graft surgery needs further investigation.

关 键 词：复合辅酶 临床推荐剂量 非体外循环 冠状动脉旁路移植术 心肌肌钙蛋白 

分 类 号：R972[医药卫生—药品]