吡贝地尔缓释片致室性早搏二联律2例  

Piribedil-induced ventricular premature beats of bigeminy in two patients

作　　者：刘平[1] 岳阳[1] 李晓荟[1] 苏宁[1] 姜树军[1] 

机构地区：[1]海军总医院干部病房神经内科,北京100048

出　　处：《中国新药杂志》2013年第11期1345-1346,共2页Chinese Journal of New Drugs

摘　　要：1例78岁老年男性帕金森病患者为控制运动症状,在多巴丝肼基础上加用吡贝地尔缓释片口服,剂量加至每日100 mg,之后出现血压偏低至100/60 mmHg,心电图提示频发室性早搏二联律,停用吡贝地尔缓释片并加用β受体阻滞剂后好转。因患者帕金森病运动症状加重,再次服用吡贝地尔缓释片每日100 mg,患者低血压、频发室性早搏二联律复现,停用后上述现象好转。1例80岁老年男性帕金森病患者吡贝地尔缓释片单药治疗运动症状,剂量加至每日100 mg后,患者出现心悸,心电图提示频发室性早搏二联律,停用吡贝地尔缓释片加用稳心颗粒后逐渐好转。两例患者均是服用吡贝地尔缓释片后出现类似心电图变化,有时间相关性,又有可重复性,考虑为该药引起的不良反应。A 78-year-old male patient with Parkinson＇s disease took 100 mg piribedil sustained-release tablet everyday after madopar treatment in order to modify the Parkinson＇s symptoms. Then, low blood pressure value of 100/60 mmHg appeared, and electrocardiogram showed ventricular premature beats of bigeminy. Those phenomena disappeared after discontinuing piribedil and taking β-blocker. However, the movement disorders were aggravated. He used piribedil again, and was forced to give up taking it because those phenomena reappeared. Another 80-years-old male patient with Parkinson＇s disease took 100 mg piribedil sustained-release tablet alone everyday to treat movement disorder. He suffered cardiopalmus, and electrocardiogram showed ventricular premature beats of bigeminy. The phenomenon disappeared after discontinuing piribedil and taking Wenxin Keli. Two patients showed the similar adverse reactions, ventricular premature beats of bigeminy, after taking piribedil sustained-release tablet. This was correlated with time and repeatable, therefore, it should be considered as the drug-caused adverse reactions.

关 键 词：吡贝地尔 帕金森病 室性早搏 二联律 药物不良反应 

分 类 号：R969.3[医药卫生—药理学]