MEF promotes stemness in the pathogenesis of gliomas  

作　　者：Bazzoli E Pulvirenti T Oberstadt MC Perna F Wee B Schultz N Huse JT Fomchenko EI Voza F Tabar V Brennan CW DeAngelis LM Nimer SD Holland EC Squatrito M 

机构地区：[1]Cancer Biology and Genetics Program,Azienda Ospedaliera Universitaria Integrata

出　　处：《中国神经肿瘤杂志》2013年第1期57-57,共1页Chinese Journal of Neuro-Oncology

摘　　要：High-grade gliomas are aggressive and uniformly fatal tumors,composed of a heterogeneous population of cells that include many with stem-cell-like properties.The acquisition of stem-like traits might contribute to glioma initiation,growth,and recurrence.Here we investigated the role of the transcription factor myeloid Elf-1 like factor(MEF,also known as ELF4) in gliomas.We found that MEF is highly expressed in both human and mouse glioblastomas and its absence impairs gliomagenesis in a PDGF-driven glioma mouse model.We show that modulation of MEF levels in both mouse neural stem cells and human glioblastoma cells has a significant impact on neurosphere formation.Moreover,we identify Sox2 as a direct downstream target of MEF.Taken together,our studies implicate MEF as a previously unrecognized gatekeeper gene in gliomagenesis that promotes stem cell characteristics through Sox2 activation.High-grade gliomas are aggressive and nniformly fatal tumors, composed of a heterogeneous population of eells that include many with stem-cell-like properties. The aequisition of sic,n-like traits might contribute to glioma initiation, growth, and recurrence. Here we investigated the role of the transcription factor myeloid Elf-1 like factor （MEF, also known as ELF4） in gliomas. We found that MEF is highly expressed in both hmnan and mouse glioblastomas and its absence impairs gliomagenesis in a Pl）GF-driven glioma mouse model. We show that modtdation of MEF levels in both mouse neural stem ceils and human glioblastoma cells has a significant impact on neurnsphere formation. Moreover, we identify Sox2 as a direet dnwnstremn larget of MEF. Taken together, our studies implicate MEF as a previously unrecognized gatekeeper gene in gliomagenesis that promntes stem cell characteristics through Sox2 activation.

关 键 词：脑胶质瘤 MEF 发病机制 干性 转录因子 小鼠模型 细胞水平 干细胞 

分 类 号：TH774[机械工程—仪器科学与技术] TP393.11[机械工程—精密仪器及机械]