吉林省医务人员乙型肝炎病毒感染现况调查  

Hepatitis B virus infection among health care workers in Jilin province of China

作　　者：马俊凤[1] 杨帅[2] 王春萍[3] 王伯莹[2] 牛俊奇[2] 闫玲[1] 孙奎霞[1] 廖雪雁[1] 聂晶晶[1] 陈杰 李杰[1] 庄辉[1] 

机构地区：[1]北京大学医学部基础医学院病原生物学系和感染病中心,北京100191 [2]吉林大学第一医院,吉林长春130021 [3]吉林省人民医院体检中心,吉林长春130021

出　　处：《中国病毒病杂志》2013年第3期205-212,共8页Chinese Journal of Viral Diseases

基　　金：国家"十二五"艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2012ZX10002001)

摘　　要：目的了解吉林省医务人员中乙型肝炎病毒(HBV)感染情况,为在医务人员中有效开展乙型肝炎(乙肝)疫苗免疫策略提供依据。方法本研究包括2 736名在职医务人员及390名退休医务人员,分别来自吉林省某医院(在职医务人员729名,退休医务人员390名)、四平市某医院(在职医务人员1 053名)、公主岭市某医院(在职医务人员954名),采用问卷调查形式收集医务人员基本信息,并用雅培ArchitectI2000分析仪检测HBV表面抗原(HBsAg)、表面抗体(抗-HBs)及核心抗体(抗-HBc)。资料用SPSS13.0软件进行统计分析。结果2 736名在职医务人员中,HBsAg、抗-HBc、抗-HBs阳性率分别为1.39%(38/2 736)、33.44%(915/2 736)和63.49%(1 737/2 736),该3项标志物全阴性者占30.81%(843/2 736)。390名退休医务人员中,HBsAg、抗-HBc和抗-HBs阳性率分别为3.33%(13/390)、61.54%(240/390)和60.77%(237/390),该3项标志物全阴性者占23.33%(91/390)。在不同年龄组的医务人员中,40～50岁和50岁以上年龄组医务人员HBsAg携带率显著高于20～30岁和30～40岁年龄组,抗-HBs阳性率低于20～30岁和30～40岁年龄组。所有医务人员中,随年龄增加,抗-HBc阳性率逐渐上升。辅助科室人员抗-HBs和抗-HBc阳性率较低,分别为52.74%(424/804)和34.08%(274/804),3项标志物全阴性率为39.80%(320/804)。结论吉林省在职医务人员HBsAg携带率和抗-HBc阳性率较低,但3项HBV血清标志物全阴性率高达30.81%,提示这部分医务人员体内无HBV保护性抗体,应接种乙肝疫苗。Objective To investigate the status of hepatitis B virus （HBV） infection among health care work ers in Jilin province of China and provide reference data for making the corresponding immunization strategy in this population. Methods An uniform questionnaires was filled out to collect the basic information of health care workers including 2 736 in-service and 390 retired staff from three hospitals in Jilin province, one hospital with 729 in-service and 390 retired staff, another in Siping city with 1 053 in-service staff and the third in Gongzhuling city with 954 in-service staff. Serum HBsAg, anti-HBs and anti-HBc were assayed by using Ab- bott Automatic Analyzer ARCHITECT I 2000 SR for statistical analysis. Results The positive rates of HB- sAg, anti-HBs and anti-HBc among 2 736 in-service staff were 1.39%, 33. 44% and 63.49%, respectively; 30.81% were negative of all three HBV markers. The positive rates of HBsAg, anti HBs and anti-HBc among390 retired staff were 3.33%, 61.54% and 60.77%, respectively; 23.33% were negative of all three HBV markers. The HBsAg positive rates in groups of ages 40 50 and ≥50 were significantly higher than that in the age group of 30-40. However, the anti HBs positive rates of the two elder groups were significantly lower than that in the younger age groups of 20-30 and 30-40. The anti-HBc positive rate gradually increased with age inall health care workers. In addition, the positive rate of anti-HBs （424/804, 52.74%） and anti HBc （274/ 804, 34.08%） in auxiliary staff group was relatively low, but the negative rate of the three HBV markers was relatively high （320/804, 39.80%）. Conclusions The positive rates of HBsAg and anti-HBc in health care workers in Jilin province were relatively low, but the negative rate of three HBV markers was as high as 30.81%, suggesting that these health care workers have no protective antibodies against HBV infection. HBV vaccination should be given to health care workers with negative HBV markers.

关 键 词：医务人员 乙型肝炎病毒 血清标志物 乙型肝炎疫苗 

分 类 号：R512.62[医药卫生—内科学]